Metabolic profiling of four synthetic stimulants, including the novel indanyl-cathinone 5-PPDi, after human hepatocyte incubation
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Other documents of the author: Fabregat-Safont, David; Mardal, Marie; Sancho, Juan V; Hernandez, Felix; Linnet, Kristjan; Ibáñez, Maria
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comunitat-uji-handle2:10234/33596
comunitat-uji-handle3:10234/33597
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Title
Metabolic profiling of four synthetic stimulants, including the novel indanyl-cathinone 5-PPDi, after human hepatocyte incubationAuthor (s)
Date
2019-12-28Publisher
ElsevierBibliographic citation
FABREGAT-SAFONT, David, et al. Metabolic profiling of four synthetic stimulants, including the novel indanyl-cathinone 5-PPDi, after human hepatocyte incubation. Journal of Pharmaceutical Analysis, 2019, 10 (2): 147-156.Type
info:eu-repo/semantics/articlePublisher version
https://www.sciencedirect.com/science/article/pii/S2095177919305404Version
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Abstract
Synthetic cathinones are new psychoactive substances that represent a health risk worldwide. For most of the 130 reported compounds, information about toxicology and/or metabolism is not available, which hampers their ... [+]
Synthetic cathinones are new psychoactive substances that represent a health risk worldwide. For most of the 130 reported compounds, information about toxicology and/or metabolism is not available, which hampers their detection (and subsequent medical treatment) in intoxication cases. The principles of forensic analytical chemistry and the use of powerful analytical techniques are indispensable for stablishing the most appropriate biomarkers for these substances. Human metabolic fate of synthetic cathinones can be assessed by the analysis of urine and blood obtained from authentic consumers; however, this type of samples is limited and difficult to access. In this work, the metabolic behaviour of three synthetic cathinones (4-CEC, 4-CPrC and 5-PPDi) and one amphetamine (3-FEA) has been evaluated by incubation with pooled human hepatocytes and metabolite identification has been performed by high-resolution mass spectrometry. This in vitro approach has previously shown its feasibility for obtaining excretory human metabolites. 4-CEC and 3-FEA were not metabolised, and for 4-CPrC only two minor metabolites were obtained. On the contrary, for the recently reported 5-PPDi, twelve phase I metabolites were elucidated. Up to our knowledge, this is the first metabolic study of an indanyl-cathinone. Data reported in this paper will allow the detection of these synthetic stimulants in intoxication cases, and will facilitate future research on the metabolic behaviour of other indanyl-based cathinones. [-]
Investigation project
Ministerio de Economía y Competitividad, Spain (Project CTQ2015-65603-P) ; Universitat Jaume I (UJI-B2018-19) ; Ministerio de Educación, Cultura y Deporte, Spain (predoctoral grant FPU15/02033) ; University of Copenhagen (EST17/00024).Rights
© 2020 Xi'an Jiaotong University. Production and hosting by Elsevier B.V.
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info:eu-repo/semantics/openAccess
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