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Inflammatory markers and bone mass in children with overweight/obesity: the role of muscular fitness
dc.contributor.author | Gil-Cosano, Jose J. | |
dc.contributor.author | Gracia-Marco, Luis | |
dc.contributor.author | Ubago-Guisado, Esther | |
dc.contributor.author | LABAYEN , IDOIA | |
dc.contributor.author | Adelantado-Renau, Mireia | |
dc.contributor.author | Cadenas-Sanchez, Cristina | |
dc.contributor.author | Mora González, José | |
dc.contributor.author | Plaza Florido, Abel Adrian | |
dc.contributor.author | Aguilera, Concepción M. | |
dc.contributor.author | Gómez Vida, José | |
dc.contributor.author | Maldonado, José | |
dc.contributor.author | Jürimäe, Jaak | |
dc.contributor.author | Ortega, Francisco B | |
dc.date.accessioned | 2020-04-30T09:28:35Z | |
dc.date.available | 2020-04-30T09:28:35Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Gil-Cosano, J.J., Gracia-Marco, L., Ubago-Guisado, E. et al. Inflammatory markers and bone mass in children with overweight/obesity: the role of muscular fitness. Pediatr Res 87, 42–47 (2020). https://doi.org/10.1038/s41390-019-0572-8 | ca_CA |
dc.identifier.issn | 0031-3998 | |
dc.identifier.issn | 1530-0447 | |
dc.identifier.uri | http://hdl.handle.net/10234/187735 | |
dc.description.abstract | Objectives To examine which inflammatory markers are associated with bone mass and whether this association varies according to muscular fitness in children with overweight/obesity. Methods Plasma interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), epidermal growth factor, vascular endothelial growth factor A (VEGF), and C-reactive protein were analyzed in 55 children aged 8–11 years. A muscular fitness score was computed. Bone mineral content (BMC) of the total body-less head (TBLH) and lumbar spine (LS) were assessed using dual-energy x-ray absorptiometry. Results IL-6 (β = −0.136) and VEGF (β = −0.099) were associated with TBLH BMC, while TNF-α (β = −0.345) and IL-1β (β = 0.212) were associated with LS BMC (P < 0.05). The interaction effect of muscular fitness showed a trend in the association of VEGF with TBLH BMC (P = 0.122) and TNF-α with LS BMC (P = 0.057). Stratified analyses by muscular fitness levels showed an inverse association of VEGF with TBLH BMC (β = −0.152) and TNF-α with LS BMC (β = −0.491) in the low-fitness group, while no association was found in the high-fitness group. Conclusion IL-6, VEGF, TNF-α, and IL-1β are significantly associated with bone mass. Higher muscular fitness may attenuate the adverse effect of high VEGF and TNF-α on bone mass. | ca_CA |
dc.format.extent | 24 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Springer Nature | ca_CA |
dc.relation.isPartOf | Pediatric Research volume 87, pages42–47(2020) | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/CNE/1.0/ | * |
dc.subject | cytokines | ca_CA |
dc.subject | growth factors | ca_CA |
dc.subject | bone health | ca_CA |
dc.subject | strength | ca_CA |
dc.subject | childhood obesity | ca_CA |
dc.title | Inflammatory markers and bone mass in children with overweight/obesity: the role of muscular fitness | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1038/s41390-019-0572-8 | |
dc.relation.projectID | BES-2014-068829, SOMM17/6107/UGR, I 2017-2021, RD16/0022, PREDOC/2015/13, FPU 16/02760, PI-0002-2017 | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.nature.com/articles/s41390-019-0572-8 | ca_CA |
dc.type.version | info:eu-repo/semantics/submittedVersion | ca_CA |
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