Use of Micellar Liquid Chromatography to Determine Mebendazole in Dairy Products and Breeding Waste from Bovine Animals
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Otros documentos de la autoría: Pawar, Rajendra-Prasad; Mishra, Pooja; Durgbanshi, Abhilasha; Bose, Devasish; Albiol Chiva, Jaume; Vives-Peris, Vicente; García Ferrer, Daniel; Esteve-Romero, Josep
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INVESTIGACIONMetadatos
Título
Use of Micellar Liquid Chromatography to Determine Mebendazole in Dairy Products and Breeding Waste from Bovine AnimalsAutoría
Fecha de publicación
2020-02-14Editor
MDPIISSN
2079-6382Cita bibliográfica
Prasad Pawar, R.; Mishra, P.; Durgbanshi, A.; Bose, D.; Albiol-Chiva, J.; Peris-Vicente, J.; García-Ferrer, D.; Esteve-Romero, J. Use of Micellar Liquid Chromatography to Determine Mebendazole in Dairy Products and Breeding Waste from Bovine Animals. Antibiotics 2020, 9, 86.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.mdpi.com/2079-6382/9/2/86/htmVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Mebendazole is an anthelmintic drug used in cattle production. However, residues may occur in produced food and in excretions, jeopardizing population health. A method based on micellar liquid chromatography (MLC) was ... [+]
Mebendazole is an anthelmintic drug used in cattle production. However, residues may occur in produced food and in excretions, jeopardizing population health. A method based on micellar liquid chromatography (MLC) was developed to determine mebendazole in dairy products (milk, cheese, butter, and curd) and nitrogenous waste (urine and dung) from bovine animals. Sample treatment was expedited to simple dilution or solid-to-liquid extraction, followed by filtration and direct injection of the obtained solution. The analyte was resolved from matrix compounds in less than 8 min, using a C18 column and a mobile phase made up of 0.15 M sodium dodecyl sulfate (SDS)–6% 1-pentanol phosphate buffered at pH 7, and running at 1 mL/min under isocratic mode. Detection was performed by absorbance at 292 nm. The procedure was validated according to the guidelines of the EU Commission Decision 2002/657/EC in terms of: specificity, method calibration range (from the limit of quantification to 25–50 ppm), sensitivity (limit of detection 0.1–0.2 ppm; limit of quantification, 0.3–0.6 ppm), trueness (92.5–102.3%), precision (<7.5%, expressed at RSD), robustness, and stability. The method is reliable, sensitive, easy-to-handle, eco-friendly, safe, inexpensive, and provides a high sample-throughput. Therefore, it is useful for routine analysis as a screening or quantification method in a laboratory for drug-residue control. [-]
Publicado en
Antibiotics 2020, 9(2)Proyecto de investigación
Regional Valencian Government “Generalitat Valenciana: AICO/2017/063; University Jaume I : UJI-B2018-20Derechos de acceso
info:eu-repo/semantics/openAccess
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