Prenatal exposure to mercury and longitudinally assesssed fetal growth: Relation and effect modifiers
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Otros documentos de la autoría: Ballester, Ferran; Íñiguez, Carmen; Murcia, Mario; Guxens, Mònica; Basterretxea, Mikel; Rebagliato, Marisa; Vioque, Jesus; Lertxundi, Aitana; Fernández Somoano, Ana; Tardon, Adonina; Sunyer Deu, Jordi; Llop, Sabrina
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https://doi.org/10.1016/j.envres.2017.09.018 |
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Título
Prenatal exposure to mercury and longitudinally assesssed fetal growth: Relation and effect modifiersAutoría
Fecha de publicación
2018-01Editor
ElsevierCita bibliográfica
BALLESTER,Ferran; ÍÑIGUEZ, Carmen;MURCIA, Mario; GUXENS, Mónica; BASTERRETXEA, Mikel; REBAGLIATO, Marisa; VIOQUE, Jesús;LERTXUNDI, Aitana; FERNÁNDEZ SOMOANO, Ana; TARDON, Adonina; SUNYER DEU, Jordi; LLOP, Sabrina (2018). Prenatal exposure to mercury and longitudinally assesssed fetal growth: Relation and effect modifiers. Environmental Research, v. 160, p. 97-106Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.sciencedirect.com/science/article/pii/S0013935117316304?via%3DihubVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Background:Prenatal mercury exposure has been related to reductions in anthropometry at birth. Levels ofmercury have been reported as being relatively elevated in the Spanish population.Objective:To investigate the ... [+]
Background:Prenatal mercury exposure has been related to reductions in anthropometry at birth. Levels ofmercury have been reported as being relatively elevated in the Spanish population.Objective:To investigate the relation between prenatal exposure to mercury and fetal growth.Methods:Study subjects were pregnant women and their newborns (n:1867) participating in a population-basedbirth cohort study set up in four Spanish regions from the INMA Project. Biparietal diameter (BPD), femur length(FL), abdominal circumference (AC), and estimated fetal weight (EFW) were measured by ultrasounds at 12, 20,and 34 weeks of gestation. Size at and growth between these points were assessed by standard deviation (SD)scores adjusted for constitutional characteristics. Total mercury (T-Hg) was determined in cord blood.Associations were investigated by linear regression models, adjusted by sociodemographic, environmental,nutritional–including four seafood groups–and lifestyle-related variables in each sub-cohort. Final estimateswere obtained using meta-analysis. Effect modification by sex, seafood intake and polychlorinated biphenyl(PCB) congener 153 concentration was assessed.Results:Geometric mean of cord blood T-Hg was 8.2μg/L. All the estimates of the association between prenatalHg and growth from 0 to 12 weeks showed reductions in SD-scores, which were only statistically significant forBPD. A doubling of cord blood T-Hg was associated with a 0.58% reduction in size of BPD at week 12 (95%confidence interval -CI-:−1.10,−0.07). Size at week 34 showed estimates suggestive of a small reduction inEFW, i.e., a doubling of T-Hg levels was associated with a reduction of 0.38% (95% CI:−0.91, 0.15). Aninteraction between PCB153 and T-Hg was found, with statistically significant negative associations of T-Hg withAC and EFW in late pregnancy among participants with PCB153 below the median.Conclusions:Exposure to mercury during pregnancy was associated with early reductions in BPD. Moreover, an antagonism with PCB 153 was observed with noteworthy reductions late in pregnancy in AC and EFW in thegroup with lower PCB153.1. [-]
Publicado en
Environmental Research (2018), v. 160, p. 97-106Proyecto de investigación
1) Instituto de SaludCarlos III (Red INMA G03/176, CB06/02/0041, FIS-FEDER 03/1615,04/1509, 04/1112, 04/1931, 04/2018, 04/1436, 05/1079, 05/1052,06/1213, 07/0314, 08/1151, 09/02647, 09/02311, 11/01007, 11/02591, 11/02038, 13/1944, 13/02429, 14/00891, 14/01687, 16/1288); 2) Miguel Servet-FEDER MS13/00054 MS15/0025); 3) Conselleria deSanitat Generalitat Valenciana, FISABIO (UGP-15-230 and 15-244); 4) Generalitat de Catalunya (CIRIT 1999SGR 00241); 5) Department ofHealth of the Basque Government (2005111093 and 2009111069); 6) Provincial Government of Gipuzkoa (DFG06/004 and DFG08/001); 7) Grants from the EU: NEWGENERIS FP6-2003-Food-3-A-016320,FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1.Derechos de acceso
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/restrictedAccess
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