Flexible high resolution-mass spectrometry approach for screening new psychoactive substances in urban wastewater
Impacto
Scholar |
Otros documentos de la autoría: Salgueiro-González, Noelia; Castiglioni, Sara; GRACIA LOR, EMMA; Bijlsma, Lubertus; Celma, Alberto; Bagnati, Renzo; Hernandez, Felix; Zuccato, Ettore
Metadatos
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INVESTIGACIONMetadatos
Título
Flexible high resolution-mass spectrometry approach for screening new psychoactive substances in urban wastewaterAutoría
Fecha de publicación
2019-11-01Editor
ElsevierCita bibliográfica
SALGUEIRO-GONZÁLEZ, Noelia, et al. Flexible high resolution-mass spectrometry approach for screening new psychoactive substances in urban wastewater. Science of The Total Environment, 2019, vol. 689, p. 679-690Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.sciencedirect.com/science/article/pii/S0048969719329092Versión
info:eu-repo/semantics/acceptedVersionPalabras clave / Materias
Resumen
The number of new psychoactive substances (NPS) on the recreational drug market has increased rapidly in the last years, creating serious challenges for public health agencies and law enforcement authorities. ... [+]
The number of new psychoactive substances (NPS) on the recreational drug market has increased rapidly in the last years, creating serious challenges for public health agencies and law enforcement authorities. Epidemiological surveys and forensic analyses to monitor the consumption of these substances face some limitations for investigating their use on a large scale in a shifting market. The aim of this work was to develop a comprehensive and flexible screening approach for assessing the presence of NPS in urban wastewater by liquid chromatography-high resolution mass spectrometry (LC-HRMS). Almost 200 substances were selected as “priority NPS” among those most frequently and recently reported by the Early Warning Systems (EWS) of different agencies and were included in the screening. Wastewater samples were collected from several cities all over Europe in 2016 and 2017, extracted using different solid-phase cartridges and analysed by LC-HRMS. The screening workflow comprised two successive analytical steps and compounds were identified and confirmed following specific criteria from the current guidelines. Thirteen NPS were identified at different confidence levels by using analytical standards or information from libraries and literature, and about half of them were phenethylamines. As far as we know, this is the first time that four of them (i.e. 3,4-dimethoxy-α-pyrrolidinovalerophenone, para-methoxyamphetamine, 2-phenethylamine and α – methyltryptamine) have been found in urban wastewater. The proposed screening approach was successfully applied in the largest NPS European wastewater monitoring, providing an innovative and easily adapted procedure for investigating NPS. In the light of current challenges and specific future research issues, this approach may complement epidemiological information and help in establishing measures for public health protection. [-]
Publicado en
Science of The Total Environment, 2019, vol. 689, p. 679-690Proyecto de investigación
This work was financially supported by the European project NPS-Euronet (HOME/2014/JDRU/AG/DRUG/7086). F. Hernandez acknowledges the financial support from the Spanish Ministry of Economy and Competitiveness (Project CTQ2015-65603-P) and A. Celma for his pre-doctoral grant (BES-2016-076914). L. Bijlsma acknowledges NPS-Euronet (HOME/2014/JDRUG/AG/DRUG/7086), co-funded by the European Union, for his post-doctoral fellowship. E. Gracia-Lor is very grateful to the Atracción de Talento Program of the Comunidad de Madrid for her postdoctoral fellowship (Ref: 2017-T2/AMB-5466).Derechos de acceso
info:eu-repo/semantics/openAccess
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