Stability studies of rifampicin in plasma and urine of tuberculosis patients according to the European Medicines Agency Guidelines
Impacto
Scholar |
Otros documentos de la autoría: Mishra, Pooja; Pawar, Rajendra-Prasad; Bose, Devasish; Durgbanshi, Abhilasha; Albiol Chiva, Jaume; Vives-Peris, Vicente; Esteve-Romero, Josep; Jain, Abhishek
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7013
comunitat-uji-handle3:10234/8638
comunitat-uji-handle4:
INVESTIGACIONEste recurso está restringido
https://doi.org/10.4155/bio-2018-0174 |
Metadatos
Título
Stability studies of rifampicin in plasma and urine of tuberculosis patients according to the European Medicines Agency GuidelinesAutoría
Fecha de publicación
2019Editor
Future ScienceISSN
1757-6180; 1757-6199Cita bibliográfica
MISHRA, Pooja, et al. Stability studies of rifampicin in plasma and urine of tuberculosis patients according to the European Medicines Agency Guidelines. Bioanalysis, 2019, vol. 11, no 08, p. 713-726Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.future-science.com/doi/abs/10.4155/bio-2018-0174Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Aim: The macrolide antibiotic rifampicin is prescribed against several infections, like tuberculosis disease. This drug decays to rifampicin quinone. Results/methodology: The biological fluids were diluted in a micellar ... [+]
Aim: The macrolide antibiotic rifampicin is prescribed against several infections, like tuberculosis disease. This drug decays to rifampicin quinone. Results/methodology: The biological fluids were diluted in a micellar solution and directly injected. Using a C18 column and a mobile phase of 0.15 M SDS-6% 1-pentanol phosphate-buffered at pH 7, running at 1 ml/min, the analytes were resolved in less than 15 min. The detection was by absorbance at 337 nm. Method was validated by the guidelines of the European Medicines Agency. Decomposition of rifampicin to rifampicin quinone was also studied. Discussion/conclusion: Procedure is rapid, easy-to-handle, economic, eco-friendly and with a high sample throughput. It was successfully used to monitor rifampicin in the plasma and urine of tubercular patients. [-]
Publicado en
Bioanalysis, 2019, vol. 11, no 8Derechos de acceso
© Future Science Group
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
Aparece en las colecciones
- QFA_Articles [813]