comunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7013
comunitat-uji-handle3:10234/8638
comunitat-uji-handle4:
INVESTIGACION
Metadades
Títol
Characterization of a recently detected halogenated aminorex derivative: para-fluoro-4-methylaminorex (4′F-4-MAR)
Data de publicació
2019
Editor
Nature Research
ISSN
2045-2322
Cita bibliogràfica
FABREGAT-SAFONT, D., et al. Characterization of a recently detected halogenated aminorex derivative: para-fluoro-4-methylaminorex (4′ F-4-MAR). Scientific reports, 2019, vol. 9, núm. 1, p. 8314
Tipus de document
info:eu-repo/semantics/article
Versió
info:eu-repo/semantics/publishedVersion
Resum
Despite the fact that 33% of the new psychoactive substances seized in 2015 were synthetic cathinones, the number of these derivatives has been decreasing in the last years, probably as a consequence of the unfavourable ... [+]
Despite the fact that 33% of the new psychoactive substances seized in 2015 were synthetic cathinones, the number of these derivatives has been decreasing in the last years, probably as a consequence of the unfavourable effects reported by users. Thus, the list of possible cathinone analogues is expected to get shorter, and it is likely that the same moiety changes applied for the preparation of synthetic cathinones will be applied in the near future to other stimulants in the search for favourable alternatives to controlled substances. This is evidenced by the increase in newly reported substances belonging to stimulant classes other than cathinones. One of the possible candidates for a new backbone from which to base new stimulants is aminorex, which is classified as a Schedule I substance by the Drug Enforcement Administration. Three derivatives have been reported until now: 4-methylaminorex or 4-MAR (also categorized as a Schedule I substance), para-methyl-4-methylaminorex (4,4′-DMAR) and 3′,4′-methylenedioxy-4-methylaminorex (MDMAR). Recently, the new halogenated 4-MAR derivative, para-fluoro-4-methylaminorex, characterised in this work (and abbreviated as pF-4-methylaminorex or 4′F-4-MAR) was detected by the Slovenian police. In the present work, 4′F-4-MAR has been characterized by high resolution mass spectrometry and nuclear magnetic resonance in a sample obtained from an anonymous consumer. This research shows that the same modifications applied for the preparation of synthetic cathinones are being used to prepare new stimulants based on the aminorex backbone. [-]
Publicat a
Scientific reports, 2019, vol. 9, núm. 1, p. 8314
Proyecto de investigación
D.F.-S., F.H. and M.I. acknowledge financial support from Generalitat Valenciana (Group of Excellence Prometeo II 2014/023, from Ministerio de Economía y Competitividad (Project: CTQ2015-65603-P, Spain) and from University Jaume I (UJI-B2018-19). Authors also acknowledge NPS-Euronet (HOME/2014/JDRUG/AG/DRUG/7086, European Union). D.F-S. acknowledges Ministerio de Educación, Cultura y Deporte for his predoctoral grant (Grant FPU15/02033, Spain). X.C., M.V. and I.F. acknowledge the grants from Subdirecció General de Drogodependències, Departament de Salut, Generalitat de Catalunya and Plan Nacional sobre Drogas.
Drets d'accés
info:eu-repo/semantics/openAccess
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