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Prenatal Omega-6:Omega-3 Ratio and Attention Deficit and Hyperactivity Disorder Symptoms
dc.contributor.author | López-Vicente, Mónica | |
dc.contributor.author | Ribas Fitó, Núria | |
dc.contributor.author | Vilor-Tejedor, Natalia | |
dc.contributor.author | Garcia, Raquel | |
dc.contributor.author | Fernández-Barrés, Sílvia | |
dc.contributor.author | Dadvand, Payam | |
dc.contributor.author | Murcia, Mario | |
dc.contributor.author | Rebagliato, Marisa | |
dc.contributor.author | Ibarluzea, Jesus | |
dc.contributor.author | Fernández Somoano, Ana | |
dc.contributor.author | Lertxundi, Aitana | |
dc.contributor.author | Fernández Somoano, Ana | |
dc.contributor.author | Tardon, Adonina | |
dc.contributor.author | López-Sabater, Maria Carmen | |
dc.contributor.author | Romaguera, Dora | |
dc.contributor.author | Vrijheid, Martine | |
dc.contributor.author | Sunyer Deu, Jordi | |
dc.contributor.author | Julvez, Jordi | |
dc.date.accessioned | 2019-06-28T10:04:48Z | |
dc.date.available | 2019-06-28T10:04:48Z | |
dc.date.issued | 2019-06 | |
dc.identifier.citation | LÓPEZ-VICENTE, Mónica, et al. Prenatal Omega-6: Omega-3 Ratio and Attention Deficit and Hyperactivity Disorder Symptoms. The Journal of Pediatrics, 2019, 209: 204-211.e4 | ca_CA |
dc.identifier.uri | http://hdl.handle.net/10234/183028 | |
dc.description.abstract | Objective To evaluate whether higher omega-6:omega-3 (n-6:n-3) long-chain polyunsaturated fatty acid ratio in cord plasma is associated with more symptoms of attention deficit and hyperactivity disorder (ADHD) at 4 and 7 years of age. Study design This study was based on a population-based birth cohort in Spain. N-6 arachidonic acid and n-3 eicosapentaenoic and docosahexaenoic acid concentrations were measured in cord plasma. At 4 years old, ADHD symptoms were reported by teachers through the ADHD Diagnostic and Statistical Manual of Mental Disorders, 4th ed checklist (n = 580). At 7 years old, ADHD symptoms were reported by parents through the Conners’ Rating Scale-Revised (short form; n = 642). The ADHD variable was treated as continuous (score) and as dichotomous (symptom diagnostic criteria). Child and family general characteristics were prospectively collected through questionnaires. We applied pooled zero-inflated negative binomial and logistic regressions adjusted for covariates. Results A higher omega-6:omega-3 long-chain polyunsaturated fatty acid ratio in cord plasma was associated with a higher ADHD index (incidence rate ratio, 1.13; 95% CI, 1.03, 1.23) at 7 years old. The association was not observed at 4 years old (incidence rate ratio, 1.04; 95% CI, 0.92-1.18). No associations were found using ADHD symptom diagnostic criteria. Conclusions High prenatal omega-6:omega-3 long-chain polyunsaturated fatty acid ratio preceded the appearance of subclinical ADHD symptoms during mid-childhood. Our findings suggest that maternal diet during pregnancy may modulate the risk to develop long-term ADHD symptoms in the offspring. | ca_CA |
dc.format.extent | 12 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.rights | © 2019 Elsevier Inc. All rights reserved. | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | population-based cohort | ca_CA |
dc.subject | children | ca_CA |
dc.subject | long-chain polyunsaturated fatty acids | ca_CA |
dc.subject | neurodevelopment | ca_CA |
dc.title | Prenatal Omega-6:Omega-3 Ratio and Attention Deficit and Hyperactivity Disorder Symptoms | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1016/j.jpeds.2019.02.022 | |
dc.relation.projectID | Spanish Institute of Health Carlos III (Co-funded by European Regional Development Fund “A way to make Europe”) (CP14/00108, PI16/00261, MS14/00108 [to J.J.]), the Agència de Gestió d’Ajuts Universitaris i de Recerca, Generalitat de Catalunya - Fons Social Europeu (2017 FI_B 00636 [to N.V-T.]), the Spanish Ministry of Science and Innovation (RYC-2012-10995 [to P.D.] and RYC-2011-08796 [to D.R.]) | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | https://www.sciencedirect.com/science/article/pii/S002234761930246X | ca_CA |
dc.contributor.funder | Obra Social Cajastur/Fundación Liberbank, Universidad de Oviedo, CIBERESP, Department of Health of the Basque Government, the Provincial Government of Gipuzkoa, the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain), Generalitat Valenciana, Generalitat de Catalunya, Fundació La marató de TV3, and the EU Commission | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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