Prenatal Omega-6:Omega-3 Ratio and Attention Deficit and Hyperactivity Disorder Symptoms
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Other documents of the author: López-Vicente, Mónica; Ribas Fitó, Núria; Vilor-Tejedor, Natalia; Garcia, Raquel; Fernández-Barrés, Sílvia; Dadvand, Payam; Murcia, Mario; Rebagliato, Marisa; Ibarluzea, Jesus; Fernández Somoano, Ana; Lertxundi, Aitana; Fernández Somoano, Ana; Tardon, Adonina; López-Sabater, Maria Carmen; Romaguera, Dora; Vrijheid, Martine; Sunyer Deu, Jordi; Julvez, Jordi
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comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
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https://doi.org/10.1016/j.jpeds.2019.02.022 |
Metadata
Title
Prenatal Omega-6:Omega-3 Ratio and Attention Deficit and Hyperactivity Disorder SymptomsAuthor (s)
Date
2019-06Publisher
ElsevierBibliographic citation
LÓPEZ-VICENTE, Mónica, et al. Prenatal Omega-6: Omega-3 Ratio and Attention Deficit and Hyperactivity Disorder Symptoms. The Journal of Pediatrics, 2019, 209: 204-211.e4Type
info:eu-repo/semantics/articlePublisher version
https://www.sciencedirect.com/science/article/pii/S002234761930246XVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
Objective
To evaluate whether higher omega-6:omega-3 (n-6:n-3) long-chain polyunsaturated fatty acid ratio in cord plasma is associated with more symptoms of attention deficit and hyperactivity disorder (ADHD) at ... [+]
Objective
To evaluate whether higher omega-6:omega-3 (n-6:n-3) long-chain polyunsaturated fatty acid ratio in cord plasma is associated with more symptoms of attention deficit and hyperactivity disorder (ADHD) at 4 and 7 years of age.
Study design
This study was based on a population-based birth cohort in Spain. N-6 arachidonic acid and n-3 eicosapentaenoic and docosahexaenoic acid concentrations were measured in cord plasma. At 4 years old, ADHD symptoms were reported by teachers through the ADHD Diagnostic and Statistical Manual of Mental Disorders, 4th ed checklist (n = 580). At 7 years old, ADHD symptoms were reported by parents through the Conners’ Rating Scale-Revised (short form; n = 642). The ADHD variable was treated as continuous (score) and as dichotomous (symptom diagnostic criteria). Child and family general characteristics were prospectively collected through questionnaires. We applied pooled zero-inflated negative binomial and logistic regressions adjusted for covariates.
Results
A higher omega-6:omega-3 long-chain polyunsaturated fatty acid ratio in cord plasma was associated with a higher ADHD index (incidence rate ratio, 1.13; 95% CI, 1.03, 1.23) at 7 years old. The association was not observed at 4 years old (incidence rate ratio, 1.04; 95% CI, 0.92-1.18). No associations were found using ADHD symptom diagnostic criteria.
Conclusions
High prenatal omega-6:omega-3 long-chain polyunsaturated fatty acid ratio preceded the appearance of subclinical ADHD symptoms during mid-childhood. Our findings suggest that maternal diet during pregnancy may modulate the risk to develop long-term ADHD symptoms in the offspring. [-]
Investigation project
Spanish Institute of Health Carlos III (Co-funded by European Regional Development Fund “A way to make Europe”) (CP14/00108, PI16/00261, MS14/00108 [to J.J.]), the Agència de Gestió d’Ajuts Universitaris i de Recerca, Generalitat de Catalunya - Fons Social Europeu (2017 FI_B 00636 [to N.V-T.]), the Spanish Ministry of Science and Innovation (RYC-2012-10995 [to P.D.] and RYC-2011-08796 [to D.R.])Rights
© 2019 Elsevier Inc. All rights reserved.
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