Repeated Working Memory Training Improves Task Performance and Neural Efficiency in Multiple Sclerosis Patients and Healthy Controls
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Other documents of the author: Aguirre, Naiara; Cruz Gómez, Álvaro Javier; Miró-Padilla, Anna; Bueichekú, Elisenda; Broseta Torres, Ricardo; Avila, Cesar; Sanchis-Segura, Carla; Forn, Cristina
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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Title
Repeated Working Memory Training Improves Task Performance and Neural Efficiency in Multiple Sclerosis Patients and Healthy ControlsAuthor (s)
Date
2019Publisher
HindawiISSN
2090-2654; 2090-2662Bibliographic citation
AGUIRRE, Naiara, et al. Repeated Working Memory Training Improves Task Performance and Neural Efficiency in Multiple Sclerosis Patients and Healthy Controls. Multiple sclerosis international, 2019, vol. 2019.Type
info:eu-repo/semantics/articlePublisher version
https://www.hindawi.com/journals/msi/2019/2657902/Version
info:eu-repo/semantics/publishedVersionAbstract
Background/Objective. To explore the efectiveness of a specifc working memory (WM) training program in MS patients and
healthy controls (HC). Method. 29 MS patients and 29 matched HC were enrolled in the study. MS ... [+]
Background/Objective. To explore the efectiveness of a specifc working memory (WM) training program in MS patients and
healthy controls (HC). Method. 29 MS patients and 29 matched HC were enrolled in the study. MS and HC were randomly split into
two groups: nontraining groups (15HC/14 MS) and training groups (14 HC/15 MS). Training groups underwent adaptive n-back
training (60 min/day; 4 days). Functional magnetic resonance imaging (fMRI) was used to monitor brain activity during n-back
performance (conditions: 0-back, 2-back, and 3-back) at 3 time points: (1) baseline, (2) post-training (+7days), and (3) followup (+35days). Results. In post-training and follow-up fMRI sessions, trained groups (HC and MS patients) exhibited signifcant
reaction time (RT) reductions and increases in Correct Responses (CRs) during 2-back and 3-back performance.Tis improvement
of task performance was accompanied by a decrease in brain activation in the WM frontoparietal network. Te two efects were
signifcantly correlated. Conclusions. Afer WM training, both cognitively preserved MS patients and HC participants showed task
performance improvement made possible by neuroplastic processes that enhanced neural efciency. [-]
Is part of
Multiple Sclerosis International Volume 2019, Article ID 2657902Investigation project
PSI2015-67285-R ; UJI B2017-05 ; FPU16/01525Rights
info:eu-repo/semantics/openAccess
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Except where otherwise noted, this item's license is described as Copyright © 2019 Naiara Aguirre et al. Tis is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.