In between molecules and self-assembled fibrillar networks: Highly stable nanogel particles from a low molecular weight hydrogelator
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Otros documentos de la autoría: Torres Martínez, Ana; Angulo-Pachón, César A.; Galindo, Francisco; Miravet, Juan
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Título
In between molecules and self-assembled fibrillar networks: Highly stable nanogel particles from a low molecular weight hydrogelatorFecha de publicación
2019-03-25Editor
Royal Society of ChemistryISSN
1744-683X; 1744-6848Cita bibliográfica
TORRES-MARTÍNEZ, Ana, et al. In between molecules and self-assembled fibrillar networks: Highly stable nanogel particles from a low molecular weight hydrogelator. Soft Matter, 2019, núm. 17, p. 3565-3572Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://pubs.rsc.org/en/content/articlelanding/2019/sm/c9sm00252a#!divAbstractVersión
info:eu-repo/semantics/acceptedVersionResumen
The preparation of molecular, non-polymeric, nanogels from a low molecular weight hydrogelator is reported. Molecular
nanogels are expected to overcome issues associated with the use of polymeric nanogels in biomedicine ... [+]
The preparation of molecular, non-polymeric, nanogels from a low molecular weight hydrogelator is reported. Molecular
nanogels are expected to overcome issues associated with the use of polymeric nanogels in biomedicine such as
biodegradability, stimuli responsiveness, polydispersity, and batch-to-batch reproducibility. Nanogels formed by compound
1 were reproducibly prepared by sonication of a xerogel in PBS, with a total concentration of ca. 2 mM. Intensity averaged
diameter of ca. 200 nm was determined by DLS. Electron microscopy (TEM and cryo-TEM) revealed spherical particles. Light
scattering (SALS) indicates that water is the main component of the nanoparticles, being the concentration of 1 in the
nanogels of ca. 3 mg/mL. These particles can be considered to constitute an intermediate state between free molecules and
self-assembled fibrillar networks. The nanogels present excellent temporal and thermal stability and accessible hydrophobic
domains, as demonstrated by the incorporation of the fluorescent dye Nile Red. [-]
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Soft Matter, 2019, núm. 17, p. 3565-3572Proyecto de investigación
Ministerio de Economía y Competitividad of Spain (grant CTQ2015-71004-R) and Universitat Jaume I (grant P1.1B2015- 76) are thanked for financial support. A.T.-M. thanks Ministerio de Educación, Cultura y Deporte of Spain for a FPU fellowship (FPU14/05974). Technical support from SCIC of University Jaume I and Dr. David Gil (CIC bioGUNE) for his assistance in cryo-TEM measurements are acknowledged.Derechos de acceso
This journal is © The Royal Society of Chemistry 2019. TORRES-MARTÍNEZ, Ana, et al. In between molecules and self-assembled fibrillar networks: Highly stable nanogel particles from a low molecular weight hydrogelator. Soft Matter, 2019, núm. 17, p. 3565-3572 <http://dx.doi.org/10.1039/C9SM00252A> -- Reproduced by permission of The Royal Society of Chemistry.
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