Mortality and cardiovascular disease burden of uncontrolled diabetes in a registry-based cohort: the ESCARVAL-risk study
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Otros documentos de la autoría: Navarro Pérez, Jorge; Orozco Beltrán, Domingo; Gil-Guillén, Vicente F; Pallarés-Carratalá, Vicente; Valls Roca, Francisco; Fernández Giménez, Antonio; Pérez Navarro, Ana M.; Sanchis-Domenech, Carlos; Dominguez-Lucas, Alejandro; Martin-Moreno, Jose M.; Redón, Josep; Tellez-Plaza, Maria; ESCARVAL Study Group, /
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INVESTIGACIONMetadatos
Título
Mortality and cardiovascular disease burden of uncontrolled diabetes in a registry-based cohort: the ESCARVAL-risk studyAutoría
Fecha de publicación
2018-09-04Editor
BMCISSN
1471-2261Cita bibliográfica
NAVARRO-PÉREZ, Jorge, et al. Mortality and cardiovascular disease burden of uncontrolled diabetes in a registry-based cohort: the ESCARVAL-risk study. BMC cardiovascular disorders, 2018, vol. 18, no 1, p. 180Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-018-0914-1Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Background:
Despite the epidemiological evidence about the relationship between diabetes, mortality and cardiovascular disease, information about the population impact of uncontrolled diabetes is scarce. We aimed ... [+]
Background:
Despite the epidemiological evidence about the relationship between diabetes, mortality and cardiovascular disease, information about the population impact of uncontrolled diabetes is scarce. We aimed to estimate the attributable risk associated with HbA1c levels for all-cause mortality and cardiovascular hospitalization.
Methods
Prospective study of subjects with diabetes mellitus using electronic health records from the universal public health system in the Valencian Community, Spain 2008–2012. We included 19,140 men and women aged 30 years or older with diabetes who underwent routine health examinations in primary care.
Results:
A total of 11,003 (57%) patients had uncontrolled diabetes defined as HbA1c ≥6.5%, and, among those, 5325 participants had HbA1c ≥7.5%. During an average follow-up time of 3.3 years, 499 deaths, 912 hospitalizations for coronary heart disease (CHD) and 786 hospitalizations for stroke were recorded. We observed a linear and increasingly positive dose-response of HbA1c levels and CHD hospitalization. The relative risk for all-cause mortality and CHD and stroke hospitalization comparing patients with and without uncontrolled diabetes was 1.29 (95 CI 1.08,1.55), 1.38 (95 CI 1.20,1.59) and 1.05 (95 CI 0.91, 1.21), respectively. The population attributable risk (PAR) associated with uncontrolled diabetes was 13.6% (95% CI; 4.0–23.9) for all-cause mortality, 17.9% (95% CI; 10.5–25.2) for CHD and 2.7% (95% CI; − 5.5-10.8) for stroke hospitalization.
Conclusions:
In a large general-practice cohort of patients with diabetes, uncontrolled glucose levels were associated with a substantial mortality and cardiovascular disease burden. [-]
Publicado en
BMC cardiovascular disorders, 2018, vol. 18, no 1Derechos de acceso
info:eu-repo/semantics/openAccess
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