Maternal copper status and neuropsychological development in infants and preschool children
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Other documents of the author: Amorós Salvador, Rubén; Murcia, Mario; González, Llúcia; Soler-Blasco, Raquel; Rebagliato, Marisa; Iñiguez, Carmen; Carrasco, Paula; Vioque, Jesus; Broberg, Karin; Levi, Michael; López Espinosa, María José; Ballester, Ferran; Llop, Sabrina
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
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https://doi.org/10.1016/j.ijheh.2019.01.007 |
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Title
Maternal copper status and neuropsychological development in infants and preschool childrenAuthor (s)
Date
2019-04Publisher
ElsevierBibliographic citation
AMORÓS, Rubén, et al. Maternal copper status and neuropsychological development in infants and preschool children. International journal of hygiene and environmental health, 2019, 222(3): 503-512Type
info:eu-repo/semantics/articlePublisher version
https://www.sciencedirect.com/science/article/pii/S1438463918307843Version
info:eu-repo/semantics/publishedVersionAbstract
Introduction
Copper (Cu) is an essential element involved in biological processes; however, excessive Cu could be harmful because of its reactive nature. Very few studies have evaluated its potential neurotoxic ... [+]
Introduction
Copper (Cu) is an essential element involved in biological processes; however, excessive Cu could be harmful because of its reactive nature. Very few studies have evaluated its potential neurotoxic effects. We aimed to evaluate the association between maternal Cu levels and children's neuropsychological development.
Methods
Study subjects were mother-child pairs from the Spanish INMA (i.e. Childhood and Environment) Project. Cu was measured by inductively coupled plasma mass spectrometry in serum samples taken at the first trimester of pregnancy (2003-2005). Neuropsychological development was assessed using the Bayley Scales of Infant Development (BSID) at 12 months (n = 651) and the McCarthy Scales of Children's Abilities (MSCA) at 5 years of age (n = 490). Covariates were obtained by questionnaires during pregnancy and childhood. Multivariate linear and non-linear models were built in order to study the association between maternal Cu and child neuropsychological development.
Results
The mean ± standard deviation of maternal Cu concentrations was 1606 ± 272 μg/L. In the multivariate analysis, a negative linear association was found between maternal Cu concentrations and both the BSID mental scale (beta = −0.051; 95% confidence intervals [CI]: −0.102, −0.001) and the MSCA verbal scale (beta = −0.044; 95%CI:-0.094, 0.006). Boys obtained poorer scores than girls, with increasing Cu at 12 months (interaction p-value = 0.040 for the mental scale and 0.074 for the psychomotor scale). This effect modification disappeared at 5 years of age. The association between Cu and the MSCA scores (verbal, perceptive performance, global memory and motor, general cognitive, and executive function scales) was negative for those children with lowest maternal iron concentrations (<938μg/L).
Conclusion
The Cu concentrations observed in our study were within the reference range established for healthy pregnant women in previous studies. The results of this study contribute to the body of scientific knowledge with important information on the possible neurotoxic capability of Cu during pregnancy. [-]
Investigation project
European Union (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), Spain (Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI14/0891, PI14/1687, PI16/1288, PI17/0663: Programa Miguel Servet-FEDER: CP11/0178, CP15/0025 and CPII16/0051; Fundació per al Foment de la Investigació Sanitària i Biomèdica de la Comunitat Valenciana – FISABIO: UGP-15-230, UGP-15-244 and UGP-15-249)Rights
© 2019 Elsevier GmbH. All rights reserved.
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