A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics
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Other documents of the author: Corella, Dolores; Coltell, Oscar; Portolés, Olga; Sotos-Prieto, Mercedes; Fernández-Carrión, Rebeca; Ramírez-Sabio, Judith B.; Zanón-Moreno, Vicente; Mattei, Josiemer; Sorlí, José V; Ordovás Muñoz, José M.
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Title
A Guide to Applying the Sex-Gender Perspective to Nutritional GenomicsAuthor (s)
Date
2019Publisher
MDPIISSN
2072-6643; 2072-6643Bibliographic citation
Corella, D.; Coltell, O.; Portolés, O.; Sotos-Prieto, M.; Fernández-Carrión, R.; Ramirez-Sabio, J.B.; Zanón-Moreno, V.; Mattei, J.; Sorlí, J.V.; Ordovas, J.M. A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics. Nutrients 2019, 11, 4.Type
info:eu-repo/semantics/articlePublisher version
https://www.mdpi.com/2072-6643/11/1/4Version
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Abstract
Precision nutrition aims to make dietary recommendations of a more personalized nature
possible, to optimize the prevention or delay of a disease and to improve health. Therefore,
the characteristics (including sex) ... [+]
Precision nutrition aims to make dietary recommendations of a more personalized nature
possible, to optimize the prevention or delay of a disease and to improve health. Therefore,
the characteristics (including sex) of an individual have to be taken into account as well as a series
of omics markers. The results of nutritional genomics studies are crucial to generate the evidence
needed so that precision nutrition can be applied. Although sex is one of the fundamental variables
for making recommendations, at present, the nutritional genomics studies undertaken have not
analyzed, systematically and with a gender perspective, the heterogeneity/homogeneity in gene-diet
interactions on the different phenotypes studied, thus there is little information available on this
issue and needs to be improved. Here we argue for the need to incorporate the gender perspective
in nutritional genomics studies, present the general context, analyze the differences between sex
and gender, as well as the limitations to measuring them and to detecting specific sex-gene or
sex-phenotype associations, both at the specific gene level or in genome-wide-association studies.
We analyzed the main sex-specific gene-diet interactions published to date and their main limitations
and present guidelines with recommendations to be followed when undertaking new nutritional
genomics studies incorporating the gender perspective. [-]
Is part of
Nutrients 2019, 11, 4.Investigation project
CIBER 06/03 ; PRX17/00500 ; PI16/00366 ; PI06/1326 ; SAF2016-80532-R ; P1-1B2013-54 ; COGRUP/2016/06 ; 538/U/2016 ; PROMETEO2017/017 ; AEST/2018/044 ; 8050-51000-098-00DRights
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