A single coating with antibacterial properties for prevention of medical device-associated infections
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Other documents of the author: García-Arnáez, Iñaki; Palla, B.; Suay, Julio; Romero-Gavilán, Francisco J; García Fernández, Luis Amable; Fernández Gutiérrez, Mar; Goñi, Isabel; Gurruchaga, Mariló
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comunitat-uji-handle2:10234/7034
comunitat-uji-handle3:10234/8619
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https://doi.org/10.1016/j.eurpolymj.2019.02.002 |
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Title
A single coating with antibacterial properties for prevention of medical device-associated infectionsAuthor (s)
Date
2019-04Publisher
ElsevierBibliographic citation
GARCÍA-ARNÁEZ, Iñaki; PALLA, B.; SUAY ANTÓN, Julio José; ROMERO-GAVILÁN, Francisco J; GARCÍA-FERNÁNDEZ, Luis; FERNÁNDEZ GUTIÉRREZ, Mar; GOÑI, Isabel; GURRUCHAGA, Mariló (2019). A single coating with antibacterial properties for prevention of medical device-associated infections. European Polymer Journal, v. 113, p. 289-296Type
info:eu-repo/semantics/articlePublisher version
https://www.sciencedirect.com/science/article/pii/S0014305718322572Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Human bacterial pathogens found on medical implants are one of the main causes of morbidity and mortality, making the development of novel coatings the primary strategy in the prevention of medical device-associated ... [+]
Human bacterial pathogens found on medical implants are one of the main causes of morbidity and mortality, making the development of novel coatings the primary strategy in the prevention of medical device-associated infections. Here, we describe organic-inorganic hybrid coatings for metallic bone implants, based on sol-gel materials of proven osteogenic capacity. The coatings were doped with two bactericides: octenidine dihydrochloride (OCT) and chlorhexidine diacetate (CHX). These bactericides, known for their efficiency, are widely used in the prevention and elimination of bacterial infections. The coatings have good chemical and mechanical properties, making them suitable for use on medical devices. They also demonstrate strong antibacterial capacity, dependent on the concentration of the bactericide. They are not toxic to human osteoblasts. Our results suggest this system as a tool for coating medical devices to prevent bacterial infections. [-]
Is part of
European Polymer Journal (2019), v. 113Investigation project
1) MINECO–Spain [MAT2017-2147-1]; 2) Basque Government [Predoc/2016/1/0141] and Ilerimplant S.L.Rights
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/restrictedAccess
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