The maternal hormone in the male brain: Sexually dimorphic distribution of prolactin signalling in the mouse brain
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Other documents of the author: Salais López, Hugo; Agustín-Pavón, Carmen; Lanuza, Enrique; Martinez-Garcia, Fernando
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Title
The maternal hormone in the male brain: Sexually dimorphic distribution of prolactin signalling in the mouse brainDate
2018Publisher
Public Library of ScienceISSN
1932-6203Bibliographic citation
Salais-Lo´pez H, Agustı´n-Pavo´n C, Lanuza E, Martı´nez-Garcı´a F (2018) The maternal hormone in the male brain: Sexually dimorphic distribution of prolactin signalling in the mouse brain. PLoS ONE 13(12): e0208960. https://doi.org/10.1371/ journal.pone.0208960Type
info:eu-repo/semantics/articleVersion
info:eu-repo/semantics/publishedVersionAbstract
Research of the central actions of prolactin is highly focused on females, but this hormone
has also documented roles in male physiology and behaviour. Here, we provide the first
description of the pattern of ... [+]
Research of the central actions of prolactin is highly focused on females, but this hormone
has also documented roles in male physiology and behaviour. Here, we provide the first
description of the pattern of prolactin-derived signalling in the male mouse brain, employing
the immunostaining of phosphorylated signal transducer and activator of transcription 5
(pSTAT5) after exogenous prolactin administration. Next, we explore possible sexually
dimorphic differences by comparing pSTAT5 immunoreactivity in prolactin-supplemented
males and females. We also assess the role of testosterone in the regulation of central
prolactin signalling in males by comparing intact with castrated prolactin-supplemented
males. Prolactin-supplemented males displayed a widespread pattern of pSTAT5 immunoreactivity, restricted to brain centres showing expression of the prolactin receptor. Immunoreactivity for pSTAT5 was present in several nuclei of the preoptic, anterior and tuberal
hypothalamus, as well as in the septofimbrial nucleus or posterodorsal medial amygdala of
the telencephalon. Conversely, non-supplemented control males were virtually devoid of
pSTAT5-immunoreactivity, suggesting that central prolactin actions in males are limited to
situations concurrent with substantial hypophyseal prolactin release (e.g. stress or mating).
Furthermore, comparison of prolactin-supplemented males and females revealed a significant, female-biased sexual dimorphism, supporting the view that prolactin has a preeminent
role in female physiology and behaviour. Finally, in males, castration significantly reduced
pSTAT5 immunoreactivity in some structures, including the paraventricular and ventromedial hypothalamic nuclei and the septofimbrial region, thus indicating a region-specific regulatory role of testosterone over central prolactin signalling. [-]
Is part of
PLoS ONE 13(12) 2018Investigation project
BFU2016-77691-C2-2-P ; BFU2016-77691-C2-1-P ; PROMETEO/2016/076 ; UJI-B2016-45 ; FPU12/05472Rights
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