Cocaine addiction affects cerebellar structure
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Title
Cocaine addiction affects cerebellar structureAuthor (s)
Tutor/Supervisor; University.Department
Barrós-Loscertales, Alfonso; Universitat Jaume I. Departament de Psicologia Bàsica, Clínica i Psicobiologia.Date
2018-07-24Publisher
Universitat Jaume IAbstract
Long term cocaine use produces structural and functional effects in different brain locations. Recent
studies point the cerebellum as one of the structures that show alterations in addicted subjects. There
are studies ... [+]
Long term cocaine use produces structural and functional effects in different brain locations. Recent
studies point the cerebellum as one of the structures that show alterations in addicted subjects. There
are studies that have documented structural differences in the cerebellum in addicted patients using
voxel-based morphometry (VBM). However, this technique has not been specially designed for the
study of the cerebellum. This study has analyzed cerebellar differences between healthy population
and patients addicted to cocaine using CERES, a technique specifically designed for the volumetric
analysis of the cerebellum. Furthermore, we explore the pharmacological treatment effects, by
differentiating those patients who supplement psychological therapy with drugs have been analyzed
separately from those who only received psychological therapy. The results show differences between
healthy population and patients treated with psychological therapy only that result in a gray matter
volume decrease in the cocaine dependent patients at the gray matter volume of the IX right lobule,
the volumetric asymmetry in IX lobule and the cortical thickness asymmetry in V lobule. On the other
hand, the results showed an increase in VIII A left lobule of cocaine dependent patients. These
differential effects were not present for the pharmacologically treated group when compared with the
control group, but a significantly greater gray matter volume in IV lobule with respect to the
psychologically treated patients group. In sum, our study suggest the effects of pharmacological
treatment during cocaine addiction treatment process that should be considered in future studies. [-]
Subject
Description
Treball Final de Màster Universitari en Investigació en Cervell i Conducta. Codi: SBM024. Curs: 2017/2018
Type
info:eu-repo/semantics/masterThesisRights
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