Role of medial prefrontal cortex in drug-cue associative memory and its functional interactions with the striatum
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Title
Role of medial prefrontal cortex in drug-cue associative memory and its functional interactions with the striatumAuthor (s)
Tutor/Supervisor; University.Department
Miquel, Marta; Gil Miravet, Isis; Universitat Jaume I. Departament de Psicologia Bàsica, Clínica i PsicobiologiaDate
2018-07-24Publisher
Universitat Jaume IAbstract
Addicts are hypersensitive to the motivational properties of stimuli associated previously with
drug taking, such as persons, places, or paraphernalia. The learned preference towards these
stimuli has been studied ... [+]
Addicts are hypersensitive to the motivational properties of stimuli associated previously with
drug taking, such as persons, places, or paraphernalia. The learned preference towards these
stimuli has been studied in animals using preference conditioning or self-administration
paradigms. Drug-cue associative learning is commonly used to investigate the motivational
effects of psychoactive drugs. Drug-cue memories depend on the so-called striatum-corticolimbic circuit. Two different loops have been described. Reinstatement of cue-induced cocaine
seeking is driven by interactions between the prelimbic (PL), nucleus accumbens core (NacC),
BLA, and tegmental ventral area VTA. However, consolidation and extinction of conditioned
cocaine seeking response is under the control of the infralimbic (IL), nucleus accumbens shell
(NacSh) and basolateral amygdala (BLA). In the present research, we tested the role that specific
regions in the mPFC play on the acquisition of cocaine-induced preference conditioning.
Moreover, we assessed the functional changes that its deactivation cause on the striatum
activity. We found that an IL deactivation promotes acquisition of cocaine-induced odor
preference conditioning while a PL impairment prevents it. Regarding the changes of the
striatum activity, neither of the unilateral deactivations of the mPFC affect c-Fos expression in
NacSh. The neural activity in this region was related with the acquisition/expression of
preference towards cocaine-related cue. PL deactivation, however, increased selectively c-Fos in
NacC core. Finally, we did not find significant effects in c-Fos expression in DMS, DLS, VLS. [-]
Subject
Màster Universitari en Investigació en Cervell i Conducta | Máster universitario en Investigación en Cerebro y Conducta | Master's Degree in Research on the Brain and Behaviour | Medial Prefrontal Cortex | Prelimbic | Infralimbic | Cocaine | Addiction | Preference Conditioning | Striatum Activity | Lidocaine
Description
Treball Final de Màster Universitari en Investigació en Cervell i Conducta. Codi: SBM024. Curs: 2017/2018
Type
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