Is self-guided internet-based cognitive behavioural therapy (iCBT) harmful? An individual participant data meta-analysis
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Otros documentos de la autoría: Karyotaki, Eirini; Kemmeren, Lise; Riper, Heleen; Twisk, Jos; Hoogendoorn, Adriaan; Kleiboer, Annet; Mira, Adriana; Mackinnon, Andrew; Meyer, Björn; Botella, Cristina; Littlewood, Elizabeth; Andersson, Gerhard; Christensen, Helen; Klein, Jan P.; Schröder, Johanna; Bretón-López, Juana; Scheider, Justine; Griffiths, Kathy; Farrer, Louise; Huibers, Marcus J. H.; Phillips, Rachel; Gilbody, Simon; Moritz, Steffen; Berger, Thomas; Pop, Victor; Spek, Viola; Cuijpers, Pim
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Título
Is self-guided internet-based cognitive behavioural therapy (iCBT) harmful? An individual participant data meta-analysisAutoría
Fecha de publicación
2018Editor
Cambridge University PressISSN
0033-2917; 1469-8978Cita bibliográfica
Karyotaki E et al (2018). Is self-guided internet-based cognitive behavioural therapy (iCBT) harmful? An individual participant data meta-analysis. Psychological Medicine 48, 2456–2466. https:// doi.org/10.1017/S0033291718000648Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.cambridge.org/core/journals/psychological-medicine/article/is-selfgu ...Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Background. Little is known about potential harmful effects as a consequence of self-guided
internet-based cognitive behaviour therapy (iCBT), such as symptom deterioration rates.
Thus, safety concerns remain and ... [+]
Background. Little is known about potential harmful effects as a consequence of self-guided
internet-based cognitive behaviour therapy (iCBT), such as symptom deterioration rates.
Thus, safety concerns remain and hamper the implementation of self-guided iCBT into clinical
practice. We aimed to conduct an individual participant data (IPD) meta-analysis to
determine the prevalence of clinically significant deterioration (symptom worsening) in adults
with depressive symptoms who received self-guided iCBT compared with control conditions.
Several socio-demographic, clinical and study-level variables were tested as potential moderators
of deterioration.
Methods. Randomised controlled trials that reported results of self-guided iCBT compared
with control conditions in adults with symptoms of depression were selected. Mixed effects
models with participants nested within studies were used to examine possible clinically significant
deterioration rates.
Results. Thirteen out of 16 eligible trials were included in the present IPD meta-analysis. Of
the 3805 participants analysed, 7.2% showed clinically significant deterioration (5.8% and
9.1% of participants in the intervention and control groups, respectively). Participants in
self-guided iCBT were less likely to deteriorate (OR 0.62, p < 0.001) compared with control
conditions. None of the examined participant- and study-level moderators were significantly
associated with deterioration rates.
Conclusions. Self-guided iCBT has a lower rate of negative outcomes on symptoms than control
conditions and could be a first step treatment approach for adult depression as well as an
alternative to watchful waiting in general practice. [-]
Publicado en
Psychological Medicine, Volume 48, Issue 15, 2018Proyecto de investigación
grant 603098 for the E-COMPARED projectDerechos de acceso
info:eu-repo/semantics/openAccess
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