Modulation of forebrain function by nucleus incertus and relaxin-3/RXFP3 signaling
Impacto
Scholar |
Otros documentos de la autoría: Olucha-Bordonau, Francisco E; Albert Gasco, Hector; Ros Bernal, Francisco; Rytova, Valeria; Ong-Pålsson, Emma K. E.; Ma, Shuai; Sánchez-Pérez, Ana María; Gundlach, Andrew Lawrence
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
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INVESTIGACIONMetadatos
Título
Modulation of forebrain function by nucleus incertus and relaxin-3/RXFP3 signalingAutoría
Fecha de publicación
2018Editor
WileyISSN
1755-5930; 1755-5949Cita bibliográfica
OLUCHA‐BORDONAU, Francisco E., et al. Modulation of forebrain function by nucleus incertus and relaxin‐3/RXFP 3 signaling. CNS neuroscience & therapeutics, 2018, vol. 24, no 8, p. 694-702Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://onlinelibrary.wiley.com/doi/full/10.1111/cns.12862Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
The nucleus incertus (NI) in the pontine tegmentum sends ascending projections to the midbrain, hypothalamus, amygdala, basal forebrain, hippocampus, and prefrontal cortex, and has a postulated role in modulating ... [+]
The nucleus incertus (NI) in the pontine tegmentum sends ascending projections to the midbrain, hypothalamus, amygdala, basal forebrain, hippocampus, and prefrontal cortex, and has a postulated role in modulating several forebrain functions. A substantial population of GABAergic NI neurons expresses the neuropeptide, relaxin‐3, which acts via the Gi/o‐protein‐coupled receptor, RXFP3, present throughout the forebrain target regions. Broad and specific manipulations of these systems by activation or inhibition of the NI or modulating RXFP3 signaling have revealed key insights into the likely influence of the NI/relaxin‐3/RXFP3 system on modalities including arousal, feeding, stress responses, anxiety and addiction, and attention and memory. This range of actions corresponds to a likely impact of NI/(relaxin‐3) projections on multiple integrated circuits, but makes it difficult to draw conclusions about a generalized function for this network. This review will focus on the key physiological process of oscillatory theta rhythm and the neural circuits that promote it during behavioral activation, highlighting the ability of NI and relaxin‐3/RXFP3 signaling systems to modulate these circuits. A better understanding of these mechanisms may provide a way to therapeutically adjust malfunction of forebrain activity present in several pathological conditions. [-]
Descripción
This is the pre-peer reviewed version of the following article: Modulation of forebrain function by nucleus incertus and relaxin‐3/RXFP3 signaling, CNS neuroscience & therapeutics, 2018, vol. 24, no 8, p. 694-702, ... [+]
This is the pre-peer reviewed version of the following article: Modulation of forebrain function by nucleus incertus and relaxin‐3/RXFP3 signaling, CNS neuroscience & therapeutics, 2018, vol. 24, no 8, p. 694-702, which has been published in final form at https://doi.org/10.1111/cns.12862. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. [-]
Publicado en
CNS neuroscience & therapeutics, 2018, vol. 24, no 8Proyecto de investigación
Universitat Jaume I / UJI-B2016-40; Spanish Ministerio de Educacion y Cultura Mobility Program / PRX17/00646; Universitat Jaume I FPI-UJI Predoctoral Research Scholarship / PREDOC/2014/35 E-2016-43; NHMRC (Australia) / 1067522; Dorothy Levien FoundationDerechos de acceso
Copyright © John Wiley & Sons, Inc.
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info:eu-repo/semantics/openAccess
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info:eu-repo/semantics/openAccess
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