Effects of lactisole on pancreatic islet B-cells electrophysiology
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comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
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Títol
Effects of lactisole on pancreatic islet B-cells electrophysiologyData de publicació
2018Editor
OATISSN
2631-441XCita bibliogràfica
SÁNCHEZ-ANDRÉS, Juan V.; MALAISSE, Willy J. Effects of lactisole on pancreatic islet B-cells electrophysiology. Clinical Nutrition and Metabolism, 2018, vol. 1, no 1Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://www.oatext.com/effects-of-lactisole-on-pancreatic-islet-b-cells-electrop ...Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Sucralose mimics the effects of glucose upon several variables of pancreatic islet B-cell metabolism and function, including bioelectrical activity. The present study aimed at investigating whether lactisole, which ... [+]
Sucralose mimics the effects of glucose upon several variables of pancreatic islet B-cell metabolism and function, including bioelectrical activity. The present study aimed at investigating whether lactisole, which was recently found to act as an antagonist of the sweet taste receptor TIR3 in pancreatic islet B-cells, also opposes the effects of glucose and/or sucralose upon B-cell electrophysiology. A dual effect of lactisole, both inhibitory and stimulatory, was observed upon the electrical activity of mouse pancreatic islet B-cells. The present findings thus document that agents supposed to act specifically on the TIR3 sweet receptor may either mimic or oppose the effect of glucose upon islet B-cell electrical activity. [-]
Publicat a
Clinical Nutrition and Metabolism, 2018, vol. 1, no 1Drets d'accés
info:eu-repo/semantics/openAccess
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