Gut–brain axis in the executive function of austism spectrum disorder
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Otros documentos de la autoría: Roman, Pablo; Rueda-Ruzafa, Lola; Cardona, Diana; Cortés Rodríguez, Alda Elena
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Gut–brain axis in the executive function of austism spectrum disorderFecha de publicación
2018Editor
Lippincott, Williams & WilkinsISSN
0955-8810; 1473-5849Cita bibliográfica
ROMAN, Pablo, et al. Gut–brain axis in the executive function of austism spectrum disorder. Behavioural Pharmacology, 2018, vol. 29, no 7, p. 654-663Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://journals.lww.com/behaviouralpharm/Abstract/2018/10000/Gut_brain_axis_in_ ...Versión
info:eu-repo/semantics/submittedVersionPalabras clave / Materias
Resumen
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication and social interactions, and repetitive behavioural patterns. These patterns are believed to be dysfunctional ... [+]
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication and social interactions, and repetitive behavioural patterns. These patterns are believed to be dysfunctional symptoms in executive processing, which impact other cognitive functions such as attention or cognitive flexibility. In recent years, several studies have shown that certain intestinal bacteria may play a role in shaping cognitive networks encompassing emotional and social domains. A microbiota–gut–brain axis is known to exist, establishing several mechanisms by which microbiota may modulate brain development, function and behaviour, including immune, endocrine and neural pathways. As the aetiology of ASD is largely unknown, some studies have shown that intestinal bacteria may be involved in its pathogenesis. The aim of this review was to focus on the role of the gut–brain axis in ASD and, specifically, on its role in executive functions. First, we summarize the relationship between the gastrointestinal and cognitive symptoms of ASD patients. In addition, we highlight the evidence that supports and emphasizes the involvement of gut microbiota, and the putative underlying mechanisms in this population. Finally, we present evidence from preclinical and clinical studies on the modulation of microbiota and their effects on cognitive symptoms, specifically in relation to executive function. In conclusion, manipulation of microbiota could be a positive intervention to improve ASD symptoms. However, more research evaluating the role of microbiota in the cognitive symptoms ASD is needed. [-]
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Behavioural Pharmacology, 2018, vol. 29, no 7Derechos de acceso
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