Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression
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Title
Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of DepressionDate
2018-06-01Publisher
Frontiers MediaBibliographic citation
LÓPEZ CRUZ, Laura; SALAMONE, John D.; CORREA SANZ, Mercé, (2018). Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression. Frontiers in Pharmacology, v. 9Type
info:eu-repo/semantics/articlePublisher version
https://www.frontiersin.org/articles/10.3389/fphar.2018.00526/fullVersion
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Abstract
Major depressive disorder is one of the most common and debilitating psychiatric
disorders. Some of the motivational symptoms of depression, such anergia (lack of
self-reported energy) and fatigue are relatively ... [+]
Major depressive disorder is one of the most common and debilitating psychiatric
disorders. Some of the motivational symptoms of depression, such anergia (lack of
self-reported energy) and fatigue are relatively resistant to traditional treatments such as
serotonin uptake inhibitors. Thus, new pharmacological targets are being investigated.
Epidemiological data suggest that caffeine consumption can have an impact on aspects
of depressive symptomatology. Caffeine is a non-selective adenosine antagonist for
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receptors, and has been demonstrated to modulate behavior in classical
animal models of depression. Moreover, selective adenosine receptor antagonists are
being assessed for their antidepressant effects in animal studies. This review focuses
on how caffeine and selective adenosine antagonists can improve different aspects
of depression in humans, as well as in animal models. The effects on motivational
symptoms of depression such as anergia, fatigue, and psychomotor slowing receive
particular attention. Thus, the ability of adenosine receptor antagonists to reverse
the anergia induced by dopamine antagonism or depletion is of special interest. In
conclusion, although further studies are needed, it appears that caffeine and selective
adenosine receptor antagonists could be therapeutic agents for the treatment of
motivational dysfunction in depression [-]
Is part of
Frontiers in Pharmacology (2018), v. 9Investigation project
1) Grant from MEC (PSI2015- 68497-R), ME- FPU (AP2010-3793) Spain, and 2) from NIH/NIMH (R03MH094966-01A1), United StatesRights
info:eu-repo/semantics/openAccess
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