comunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
comunitat-uji-handle4:
INVESTIGACION
Resumen
Objective: This review aims to summarize the current literature on patient-reported outcomes
(PROs) in spondyloarthritis (SpA).
Patients and methods: We performed a systematic literature review to identify studies ... [+]
Objective: This review aims to summarize the current literature on patient-reported outcomes
(PROs) in spondyloarthritis (SpA).
Patients and methods: We performed a systematic literature review to identify studies (original
articles and narrative and systematic reviews) regarding PROs (health-related quality of life
[HRQoL], satisfaction, preferences, adherence/compliance, and persistence) in SpA patients
published in the European Union through December 2016. International databases (Medline/
PubMed, Cochrane Library, ISI Web of Knowledge, Scopus) were searched using keywords
in English. The methodological quality of the studies was assessed using the Oxford Centre for
Evidence-Based Medicine criteria.
Results: A total of 26 publications met the inclusion criteria. Generally, studies indicated
that SpA has a negative impact on patients’ HRQoL. In patients with ankylosing spondylitis,
physical domains were more affected than emotional ones, whereas for psoriatic arthritis, both
physical and psychological factors were strongly affected by the disease. Data indicated that
biological agents (BAs) greatly contributed to improvement in HRQoL in both ankylosing
spondylitis and psoriatic arthritis patients. Findings on compliance with BAs were heterogeneous.
However, persistence rates exceeded 50% irrespective of the BA administered. Results
on preferences indicated that most SpA patients prefer being involved in decisions regarding
their treatment and that besides efficacy and safety, frequency and route of administration may
influence patients’ preferences for BAs.
Conclusion: Implementing management programs for SpA patients focuses on the physical,
emotional, and social consequences of the disease, in addition to assessing and including patient
preferences in the treatment decision-making process, could be crucial to improve patients’
HRQoL and ensure their satisfaction and compliance with treatment. [-]
Derechos de acceso
info:eu-repo/semantics/openAccess