Design and Synthesis of Cysteine Protease Inhibitors
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INVESTIGACIONMetadata
Title
Design and Synthesis of Cysteine Protease InhibitorsAuthor (s)
Date
2017-09-08Publisher
MDPIISSN
2504-3900Bibliographic citation
Gonzalez, Florenci V. 2017. "Design and Synthesis of Cysteine Protease Inhibitors." Proceedings 1, no. 6: 672.Type
info:eu-repo/semantics/conferenceObjectPublisher version
http://www.mdpi.com/2504-3900/1/6/672Version
info:eu-repo/semantics/publishedVersionAbstract
We have been preparing new dipeptidyl inhibitors against parasitic cysteine proteases cruzain (related to Chagas disease) and rhodesain (related to Sleeping Sickness disease), and against human cathepsins. Inhibitors ... [+]
We have been preparing new dipeptidyl inhibitors against parasitic cysteine proteases cruzain (related to Chagas disease) and rhodesain (related to Sleeping Sickness disease), and against human cathepsins. Inhibitors display new warheads embedded into a dipeptidic framework. Dipeptidyl epoxyesters1 and Dipeptidyl enoates2 are highly potent irreversible inhibitors of cruzain and rhodesain. We also prepared an oxidized version of well-known Vinylsulfones (Epoxysulfones3) as inhibitors of human cathepsins. Recently, we have reported the synthesis of Dipeptidyl nitroalkenes4 as a new type of highly potent covalent reversible inhibitors of cysteine proteases exhibiting certain selectivity for the parasitic cysteine proteases rhodesain and cruzain. [-]
Description
Resum de la ponència presentada al 1st Molecules Medicinal Chemistry Symposium. Barcelona, 8 september 2017
Is part of
1st Molecules Medicinal Chemistry Symposium. Barcelona, 8 september 2017Related data
https://sciforum.net/conference/MMCS2017/MMCS%202017-Second%20Session:%20To%20be%20determinedInvestigation project
Generalitat Valenciana (AICO/2016/32)Rights
info:eu-repo/semantics/openAccess
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