Accurate cut-offs for predicting endoscopic activity and mucosal healing in Crohn’s disease with fecal calprotectin
Ver/ Abrir
Impacto
Scholar |
Otros documentos de la autoría: Vázquez Morón, Juan María; Pallarés Manrique, Héctor; Machancoses, Francisco H.; Ramos Lora, Manuel; Ruiz Frutos, Carlos
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8034
comunitat-uji-handle3:10234/8637
comunitat-uji-handle4:
INVESTIGACIONMetadatos
Título
Accurate cut-offs for predicting endoscopic activity and mucosal healing in Crohn’s disease with fecal calprotectinAutoría
Fecha de publicación
2017Editor
ARAN edicionesCita bibliográfica
VÁZQUEZ-MORÓN, Juan María, et al. Accurate cut-offs for predicting endoscopic activity and mucosal healing in Crohn's disease with fecal calprotectin. Revista Española de Enfermedades Digestivas, 2017, vol. 109, núm. 2, p.130-136Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.reed.es/ArticuloFicha.aspx?id=1432&hst=0&idR=45&tp=1&AspxAutoDetectC ...Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Background: Fecal biomarkers, especially fecal calprotectin,
are useful for predicting endoscopic activity in Crohn’s disease;
however, the cut-off point remains unclear. The aim of this paper
was to analyze whether ... [+]
Background: Fecal biomarkers, especially fecal calprotectin,
are useful for predicting endoscopic activity in Crohn’s disease;
however, the cut-off point remains unclear. The aim of this paper
was to analyze whether faecal calprotectin and M2 pyruvate
kinase are good tools for generating highly accurate scores for the
prediction of the state of endoscopic activity and mucosal healing.
Methods: The simple endoscopic score for Crohn’s disease
and the Crohn’s disease activity index was calculated for 71
patients diagnosed with Crohn’s. Fecal calprotectin and M2-PK
were measured by the enzyme-linked immunosorbent assay test.
Results: A fecal calprotectin cut-off concentration of ≥ 170
μg/g (sensitivity 77.6%, specificity 95.5% and likelihood ratio
+17.06) predicts a high probability of endoscopic activity, and a
fecal calprotectin cut-off of ≤ 71 μg/g (sensitivity 95.9%, specificity
52.3% and likelihood ratio -0.08) predicts a high probability of
mucosal healing. Three clinical groups were identified according to
the data obtained: endoscopic activity (calprotectin ≥ 170), mucosal
healing (calprotectin ≤ 71) and uncertainty (71 > calprotectin <
170), with significant differences in endoscopic values (F = 26.407,
p < 0.01). Clinical activity or remission modified the probabilities of
presenting endoscopic activity (100% vs 89%) or mucosal healing
(75% vs 87%) in the diagnostic scores generated. M2-PK was
insufficiently accurate to determine scores.
Conclusions: The highly accurate scores for fecal calprotectin
provide a useful tool for interpreting the probabilities of presenting
endoscopic activity or mucosal healing, and are valuable in the
specific clinical context. [-]
Publicado en
Revista Española de Enfermedades Digestivas, 2017, vol. 109, núm. 2, p.130-136Derechos de acceso
La Revista Española de Enfermedades Digestivas (REED) es una revista open access, lo que quiere decir que todo su contenido es accesible libremente sin cargo para el usuario individual y sin fines comerciales.
Los usuarios individuales están autorizados a leer, descargar, copiar, distribuir, imprimir, buscar o enlazar a los textos completos de los artículos de esta revista sin permiso previo del editor o del autor, de acuerdo con la definición BOAI (Budapest Open Access Initiative) de open access.
La reutilización de los trabajos puede hacerse siempre y cuando el trabajo no se altere en su integridad y sus autores sean adecuadamente referenciados o citados en sucesivos usos, y sin derecho a la producción de obras derivadas.
© Copyright 2018. Sociedad Española de Patología Digestiva (SEPD) y © Arán Ediciones, S.L.
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
Aparece en las colecciones
- PSI_Articles [589]