Evidence for degraded low frequency verbal concepts in left resected temporal lobe epilepsy patients
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Other documents of the author: Visser, Maya; Forn, Cristina; Lambon Ralph, Matthew A.; Hoffman, P.; Gómez Ibáñez, A.; Sanjuán Tomás, Ana; Rossell Negre, P.; Villanueva, Vicente; Avila, Cesar
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comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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Title
Evidence for degraded low frequency verbal concepts in left resected temporal lobe epilepsy patientsAuthor (s)
Date
2018Publisher
ElsevierISSN
0028-3932; 1873-3514Type
info:eu-repo/semantics/articlePublisher version
https://www.sciencedirect.com/science/article/pii/S0028393218301611Version
info:eu-repo/semantics/submittedVersionSubject
Abstract
According to a large neuropsychological and neuroimaging literature, the bilateral
anterior temporal lobe (ATL) is a core region for semantic processing. It seems
therefore surprising that semantic memory appears ... [+]
According to a large neuropsychological and neuroimaging literature, the bilateral
anterior temporal lobe (ATL) is a core region for semantic processing. It seems
therefore surprising that semantic memory appears to be preserved in temporal lobe
epilepsy (TLE) patients with unilateral ATL resection. However, recent work suggests
that the bilateral semantic system is relatively robust against unilateral damage and
semantic impairments under these circumstances only become apparent with low
frequency specific concepts. In addition, neuroimaging studies have shown that the
function of the left and right ATLs differ and therefore left or right ATL resection
should lead to a different pattern of impairment. The current study investigated
hemispheric differences in the bilateral semantic system by comparing left and right
resected TLE patients during verbal semantic processing of low frequency concepts.
Picture naming and semantic comprehension tasks with varying word frequencies were
included to investigate the pattern of impairment. Left but not right TLE patients
showed impaired semantic processing, which was particularly apparent on low
frequency items. This indicates that, for verbal information, the bilateral semantic
system is more sensitive to damage in the left compared to the right ATL, which is in
line with theories that attribute a more prominent role to the left ATL due to
connections with pre-semantic verbal regions. [-]
Is part of
Neuropsychologia, 23 April 2018Investigation project
PSI2013-45378-R ; P1·1B2014-03Rights
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