Efficient and Selective N‐Methylation of Nitroarenes under Mild Reaction Conditions
Impacto
Scholar |
Otros documentos de la autoría: Pedrajas Gual, Elena; Sorribes, Iván; Guillamón, Eva; Junge, Henrik; Beller, matthias; Llusar, Rosa
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7013
comunitat-uji-handle3:10234/8638
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INVESTIGACIONMetadatos
Título
Efficient and Selective N‐Methylation of Nitroarenes under Mild Reaction ConditionsAutoría
Fecha de publicación
2017Editor
WileyISSN
0947-6539; 1521-3765Cita bibliográfica
PEDRAJAS, Elena, et al. Efficient and Selective N‐Methylation of Nitroarenes under Mild Reaction Conditions. Chemistry–A European Journal, 2017, vol. 23, no 53, p. 13205-13212.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201702783Versión
info:eu-repo/semantics/acceptedVersionPalabras clave / Materias
Resumen
Herein, we report a straightforward protocol for the preparation of N,N‐dimethylated amines from readily available nitro starting materials using formic acid as a renewable C1 source and silanes as reducing agents. ... [+]
Herein, we report a straightforward protocol for the preparation of N,N‐dimethylated amines from readily available nitro starting materials using formic acid as a renewable C1 source and silanes as reducing agents. This tandem process is efficiently accomplished in the presence of a cubane‐type Mo3PtS4 catalyst. For the preparation of the novel [Mo3Pt(PPh3)S4Cl3(dmen)3]+ (3+) (dmen: N,N′‐dimethylethylenediamine) compound we have followed a [3+1] building block strategy starting from the trinuclear [Mo3S4Cl3(dmen)3]+ (1+) and Pt(PPh3)4 (2) complexes. The heterobimetallic 3+ cation preserves the main structural features of its 1+ cluster precursor. Interestingly, this catalytic protocol operates at room temperature with high chemoselectivity when the 3+ catalyst co‐exists with its trinuclear 1+ precursor. N‐heterocyclic arenes, double bonds, ketones, cyanides and ester functional groups are well retained after N‐methylation of the corresponding functionalized nitroarenes. In addition, benzylic‐type as well as aliphatic nitro compounds can also be methylated following this protocol. [-]
Publicado en
Chemistry–A European Journal, 2017, vol. 23, no 53Proyecto de investigación
Spanish Ministerio de Economía y Competitividad: Grant CTQ2015‐65207‐P), Generalitat Valenciana: PrometeoII/2014/022) , Universitat Jaume I: UJI‐A2016‐05Derechos de acceso
Copyright © John Wiley & Sons, Inc.
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info:eu-repo/semantics/openAccess
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info:eu-repo/semantics/openAccess
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