Insulin signaling in hippocampus
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Insulin signaling in hippocampusAutoria
Tutor/Supervisor; Universitat.Departament
Sánchez-Pérez, Ana María; Universitat Jaume I. Unitat Predepartamental de MedicinaData de publicació
2017-09-21Editor
Universitat Jaume IResum
Neuroinflammation and insulin resistance are known to underlie many neurological
alterations, including Alzheimer's disease. Neuroinflammation is associated with chronic
microglia activation, which ... [+]
Neuroinflammation and insulin resistance are known to underlie many neurological
alterations, including Alzheimer's disease. Neuroinflammation is associated with chronic
microglia activation, which induces synaptic loss, and neuronal damage. Insuli
n
resistance, on the other hand is associated with deregulation of insulin receptor substrates
(IRS
-
1 and IRS
-
2). Alzheimer's disease is the leading cause of dementia and is
characterized by progressive, degenerative and irreversible neurological disorder
, in
which loss of memory and behavioral changes are observed. Given the importance of
IRS1 and IRS2 in mediating insulin effects in brain, this study focuses on the distribution
of these proteins in hippocampus. In addition, we aimed to evaluate the effec
t of the
phytohormone abscisic acid (ABA) in hippocampal neurogenesis in a model of
neuroinflammation. ABA has been shown to be an insulin sensitizer in periphery and
having anti
-
inflammatory properties also in central nervous system. The results indicated
differences on the distribution, morphology and expression of insulin receptor substrates
(IRS
-
1 and IRS
-
2) in the hippocampus. We also observed lower levels of neurogenesis
in animals treated with fat diet, suggesting an influence of diet type on these
levels in the
hippocampus. [-]
Paraules clau / Matèries
Descripció
Treball Final de Màster Universitari en Investigació en Cervell i Conducta. Codi: SBM024. Curs: 2016/2017
Tipus de document
info:eu-repo/semantics/masterThesisDrets d'accés
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info:eu-repo/semantics/restrictedAccess