Oral Ingestion and Intraventricular Injection of Curcumin Attenuates the Effort-Related Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Motivational Symptoms of Depression
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Other documents of the author: Yohn, Samantha E.; Gorka, Dea; Mistry, Anisha; Collins, Samantha; Qian, Emily; Correa, Merce; Manchanda, Arushi; Bogner, Robin; Salamone, John
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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http://dx.doi.org/10.1021/acs.jnatprod.7b00425 |
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Title
Oral Ingestion and Intraventricular Injection of Curcumin Attenuates the Effort-Related Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Motivational Symptoms of DepressionAuthor (s)
Date
2017-09Publisher
American Chemical SocietyBibliographic citation
YOHN, Samantha E., et al. Oral Ingestion and Intraventricular Injection of Curcumin Attenuates the Effort-Related Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Motivational Symptoms of Depression. Journal of natural products, 2017, vol. 80, no 10, p. 2839-2844.Type
info:eu-repo/semantics/articlePublisher version
https://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.7b00425Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Effort-related choice tasks are used for studying depressive motivational symptoms such as anergia/fatigue. These studies investigated the ability of the dietary supplement curcumin to reverse the low-effort bias ... [+]
Effort-related choice tasks are used for studying depressive motivational symptoms such as anergia/fatigue. These studies investigated the ability of the dietary supplement curcumin to reverse the low-effort bias induced by the monoamine storage blocker tetrabenazine. Tetrabenazine shifted effort-related choice in rats, decreasing high-effort lever pressing but increasing chow intake. The effects of tetrabenazine were reversed by oral ingestion of curcumin (80.0–160.0 mg/kg) and infusions of curcumin into the cerebral ventricles (2.0–8.0 μg). Curcumin attenuates the effort-related effects of tetrabenazine in this model via actions on the brain, suggesting that curcumin may be useful for treating human motivational symptoms. [-]
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- PSB_Articles [1294]