Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK study
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Other documents of the author: Orozco Beltrán, Domingo; Gil-Guillén, Vicente F; Redón, Josep; Martin-Moreno, Jose M.; Pallarés-Carratalá, Vicente; Navarro Pérez, Jorge; Valls Roca, Francisco; Sanchis-Domenech, Carlos; Fernández Giménez, Antonio; Pérez Navarro, Ana M.; Bertomeu-Martínez, Vicente; Cordero, Alberto; Pascual de la Torre, Manuel; Trillo, José L.; Carratala-Munuera, Concepcion; Pita Fernández, Salvador; Usó, Ruth; Durazo-Arvizu, Ramon; Cooper, Richard; Sanz, Ginés; Castellano, José M.; Ascaso, Juan F; Carmena, Rafael; Tellez-Plaza, Maria; ESCARVAL Study Group; Bertomeu-González, Vicente
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comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
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INVESTIGACIONMetadata
Title
Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK studyAuthor (s)
Date
2017Publisher
Public Library of ScienceISSN
1932-6203Bibliographic citation
Orozco-Beltran D, Gil-Guillen VF, Redon J, Martin-Moreno JM, Pallares-Carratala V, NavarroPerez J, et al. (2017) Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK study. PLoS ONE 12(10): e0186196. https://doi.org/10.1371/journal. pone.0186196Type
info:eu-repo/semantics/articlePublisher version
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186196Version
info:eu-repo/semantics/publishedVersionAbstract
Introduction
The potential impact of targeting different components of an adverse lipid profile in populations with multiple cardiovascular risk factors is not completely clear. This study aims to assess the association ... [+]
Introduction
The potential impact of targeting different components of an adverse lipid profile in populations with multiple cardiovascular risk factors is not completely clear. This study aims to assess the association between different components of the standard lipid profile with all-cause mortality and hospitalization due to cardiovascular events in a high-risk population.
Methods
This prospective registry included high risk adults over 30 years old free of cardiovascular disease (2008–2012). Diagnosis of hypertension, dyslipidemia or diabetes mellitus was inclusion criterion. Lipid biomarkers were evaluated. Primary endpoints were all-cause mortality and hospital admission due to coronary heart disease or stroke. We estimated adjusted rate ratios (aRR), absolute risk differences and population attributable risk associated with adverse lipid profiles.
Results
51,462 subjects were included with a mean age of 62.6 years (47.6% men). During an average follow-up of 3.2 years, 919 deaths, 1666 hospitalizations for coronary heart disease and 1510 hospitalizations for stroke were recorded. The parameters that showed an increased rate for total mortality, coronary heart disease and stroke hospitalization were, respectively, low HDL-Cholesterol: aRR 1.25, 1.29 and 1.23; high Total/HDL-Cholesterol: aRR 1.22, 1.38 and 1.25; and high Triglycerides/HDL-Cholesterol: aRR 1.21, 1.30, 1.09. The parameters that showed highest population attributable risk (%) were, respectively, low HDL-Cholesterol: 7.70, 11.42, 8.40; high Total/HDL-Cholesterol: 6.55, 12.47, 8.73; and high Triglycerides/HDL-Cholesterol: 8.94, 15.09, 6.92.
Conclusions
In a population with cardiovascular risk factors, HDL-cholesterol, Total/HDL-cholesterol and triglycerides/HDL-cholesterol ratios were associated with a higher population attributable risk for cardiovascular disease compared to other common biomarkers. [-]
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