comunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7013
comunitat-uji-handle3:10234/8638
comunitat-uji-handle4:
INVESTIGACION
Metadata
Title
Updating the list of known opioids through identification and characterization of the new opioid derivative 3,4-dichloro-N- (2-(diethylamino)cyclohexyl)-N- methylbenzamide (U-49900)
Date
2017
Publisher
Springer Nature
ISSN
2045-2322; 2045-2322
Bibliographic citation
Fabregat-Safont, D., Carbón, X., Ventura, M., Fornís, I., Guillamón, E., Sancho, J. V., ... & Ibáñez, M. (2017). Updating the list of known opioids through identification and characterization of the new opioid derivative 3, 4-dichloro-N-(2-(diethylamino) cyclohexyl)-N-methylbenzamide (U-49900). Scientific Reports, 7(1), 6338.
Type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Abstract
New psychoactive substances have been rapidly growing in popularity in the drug market as non-illegal drugs. In the last few years, an increment has been reported on the use of synthetic alternatives to heroin, the ... [+]
New psychoactive substances have been rapidly growing in popularity in the drug market as non-illegal drugs. In the last few years, an increment has been reported on the use of synthetic alternatives to heroin, the synthetic opioids. Based on the information provided by the European Monitoring Centre for Drug and Drug Addiction, these synthetic opioids have been related to overdoses and deaths in Europe and North America. One of these opioids is the U-47700. A few months ago, U-47700 was scheduled in the U.S. and other countries, and other opioid derivatives have been appearing in order to replace it. One of these compounds is U-49900, an analog of U-47700. A white powder sample was obtained from an anonymous user in Spain. After an accurate characterization by gas chromatography-mass spectrometry, ultra-high performance liquid chromatography-high resolution mass spectrometry, nuclear magnetic resonance and single-crystal X-ray diffraction; and complemented by Fourier-transformed infrared spectroscopy, ultraviolet and circular dichroism spectrophotometry, the drug sample was unequivocally identified as U-49900. The information provided will be useful for the Early Warning System and forensic laboratories for future identifications of the U-49900, as well as in tentative identifications of other related opioids. [-]
Is part of
Scientific Reports, 2017, vol. 7, núm. 1, p. 6338
Investigation project
D.F.-S., J.V.S., F.H. and M.I. acknowledge financial support from Generalitat Valenciana (Group of Excellence Prometeo II 2014/023) and from Ministerio de Economía y Competitividad in Spain (Project: CTQ2015-65603-P). D.F.-S., J.V.S., F.H. and M.I. also acknowledge NPS-Euronet (HOME/2014/JDRUG/AG/DRUG/7086), co-funded by the European Commission. This publication reflects the views only of the authors, and the European Commission cannot be held responsible for any use which may be made of the information contained therein. The authors are very grateful to the Serveis Centrals d’Instrumentació Científica (SCIC) of University Jaume I (UJI) for the use of NMR, X-ray diffractometer, FTIR and UV. They also wish to thank Cristian Vicent (SCIC), Gabriel Peris (SCIC), José Pedra (SCIC) and Florenci V. González (UJI) for skillful technical assistance and useful comments. D.F.-S. acknowledges Ministerio de Educación, Cultura y Deporte in Spain for his predoctoral grant (Grant FPU15/2033). X.C., M.V. and I.F. acknowledge the grants from Subdirecció General de Drogodependències, Departament de Salut, Generalitat de Catalunya and Plan Nacional sobre Drogas in Spain.
Rights
info:eu-repo/semantics/openAccess
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