Brain insulin signaling in Alzheimer's disease
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comunitat-uji-handle3:10234/167590
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Title
Brain insulin signaling in Alzheimer's diseaseAuthor (s)
Tutor/Supervisor; University.Department
Sánchez Pérez, Ana María; Universitat Jaume I. Unitat Predepartamental de MedicinaDate
2017Publisher
Universitat Jaume IAbstract
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder and the most
common cause of dementia affecting elderly people. Its pathological hallmarks are the
presence of extracellular aggregates of amyloid-β ... [+]
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder and the most
common cause of dementia affecting elderly people. Its pathological hallmarks are the
presence of extracellular aggregates of amyloid-β peptide (Aβ), also known as senile
plaques, and intracellular clusters of hyperphosphorylated tau protein, commonly
called neurofibrillary tangles (NFTs). Classically, the brain was considered to be
insulin-insensitive, but evidence has proved the contrary and now it is widely accepted
that insulin and IGF-1 have neuromodulatory actions. Insulin signaling is involved in
various neuronal functions such as synapse transmission, cognition, learning and
memory. Insulin resistance, together with AβOs neurotoxicity, neuronal metabolic
stress and neuroinflammation, has been shown to play a role in AD pathogenesis. In
this review we will describe the connection between neuronal insulin signaling and the
pathogenesis and progression of AD, as well as the new promising therapeutic
approaches focused on the insulin signaling pathway that are being researched, such
as intranasal insulin or insulin sensitizing agents. [-]
Subject
Description
Treball Final de Grau en Medicina. Codi: MD1158. Curs acadèmic: 2016-2017
Type
info:eu-repo/semantics/bachelorThesisRights
Licencia CC-BY-NC-SA
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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- Grau en Medicina [494]
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