Reduced activity in functional networks during reward processing is modulated by abstinence in cocaine addicts
Impacto
Scholar |
Otros documentos de la autoría: Costumero, Víctor; Bustamante, Juan Carlos; Rosell Negre, Patricia; Fuentes-Claramonte, Paola; Llopis, Juan José; Avila, Cesar; Barrós-Loscertales, Alfonso
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http://dx.doi.org/10.1111/adb.12329 |
Metadatos
Título
Reduced activity in functional networks during reward processing is modulated by abstinence in cocaine addictsAutoría
Fecha de publicación
2017-03Editor
WileyISSN
1355-6215; 1369-1600Cita bibliográfica
COSTUMERO, Víctor, et al. Reduced activity in functional networks during reward processing is modulated by abstinence in cocaine addicts. Addiction biology, 2017, vol. 22, no 2, p. 479-489.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://onlinelibrary.wiley.com/doi/10.1111/adb.12329/fullVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Cocaine addiction is characterized by alterations in motivational and cognitive processes. Recent studies have shown that some alterations present in cocaine users may be related to the activity of large functional ... [+]
Cocaine addiction is characterized by alterations in motivational and cognitive processes. Recent studies have shown that some alterations present in cocaine users may be related to the activity of large functional networks. The aim of this study was to investigate how these functional networks are modulated by non-drug rewarding stimuli in cocaine-dependent individuals. Twenty abstinent cocaine-dependent and 21 healthy matched male controls viewed erotic and neutral pictures while undergoing a functional magnetic resonance imaging scan. Group independent component analysis was then performed in order to investigate how functional networks were modulated by reward in cocaine addicts. The results showed that cocaine addicts, compared with healthy controls, displayed diminished modulation of the left frontoparietal network in response to erotic pictures, specifically when they were unpredicted. Additionally, a positive correlation between the length of cocaine abstinence and the modulation of the left frontoparietal network by unpredicted erotic images was found. In agreement with current addiction models, our results suggest that cocaine addiction contributes to reduce sensitivity to rewarding stimuli and that abstinence may mitigate this effect. [-]
Publicado en
Addiction biology, 2017, vol. 22, no 2, p. 479-489Proyecto de investigación
MINECO / PSI2010-20168; Universitat Jaume I / P1_1B2011-09; Spanish National Drug Strategy Ministerio de Sanidad y Consumo / 040/2011; Ministerio de Economia y Competitividad / PSI2012-33054Derechos de acceso
Copyright © John Wiley & Sons, Inc. All Rights Reserved
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