Should clinically meaninglul outcomes in cancer be based on individual survival rather than median overall survival?
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Other documents of the author: Sacristán, José Antonio; Dilla, Tatiana; Garrido, Pilar; Avendaño, Cristina; Cruz-Hernández, Juan J.; Espinosa, Javier; Comellas, Marta; Lizán, Luis
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https://doi.org/10.2217/cer-2016-0081 |
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Title
Should clinically meaninglul outcomes in cancer be based on individual survival rather than median overall survival?Author (s)
Date
2017-09Publisher
Future MedicineBibliographic citation
SACRISTÁN, José A., et al. Should clinically meaningful outcomes in cancer be based on individual survival rather than median overall survival?. Journal of comparative effectiveness research, 2017, vol. 6, no 6, p. 491-495.Type
info:eu-repo/semantics/articlePublisher version
https://www.researchgate.net/publication/320109677_Should_clinically_meaningful_ ...Version
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Abstract
Aim: To assess whether the use of median overall survival to define clinically meaningful outcomes in the area of oncology could yield different decisions compared with those obtained with a more realistic measure ... [+]
Aim: To assess whether the use of median overall survival to define clinically meaningful outcomes in the area of oncology could yield different decisions compared with those obtained with a more realistic measure such as individual survival. Methods: Two scenarios that offered equivalent health gains/money spent were presented: ‘median overall survival’ scenario (new treatment provided small clinical benefits for the average population) and ‘individual survival’scenario (new treatment provided substantial clinical benefits for a small percentage of the patients and no benefits for the rest). Responses from both scenarios were compared. Results: Responses between the two scenarios were different for oncologists, healthcare policy makers and patients (p < 0.05). ‘Individual survival’ scenario obtained higher percentage of positive answers compared with ‘median overall survival’. Conclusion: Expressing the benefits of new oncologic treatments in terms of ‘individual survival’ may yield to different healthcare decisions compared with the widely used median overall survival. [-]
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© 2017 Future Medicine Ltd.
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