Naloxone effects on extinction of ethanol- and cocaine-induced conditioned place preference in mice
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Scholar |
Otros documentos de la autoría: Font Hurtado, Laura; Houck, Christa A.; Cunningham, Christopher L.
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http://doi.org/10.1007/s00213-017-4672-z |
Metadatos
Título
Naloxone effects on extinction of ethanol- and cocaine-induced conditioned place preference in miceFecha de publicación
2017Editor
Springer VerlagISSN
0033-3158; 1432-2072Cita bibliográfica
Font, L., Houck, C.A. & Cunningham, C.L. Psychopharmacology (2017) 234: 2747. https://doi.org/10.1007/s00213-017-4672-zTipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://link.springer.com/article/10.1007/s00213-017-4672-z#citeasVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Rationale
Previous studies found that naloxone (NLX) facilitated choice extinction of ethanol conditioned place preference (CPP) using long (60 min) test sessions, but there is little information on the variables ... [+]
Rationale
Previous studies found that naloxone (NLX) facilitated choice extinction of ethanol conditioned place preference (CPP) using long (60 min) test sessions, but there is little information on the variables determining this effect.
Objectives
These studies examined repeated exposure to NLX during extinction of ethanol- or cocaine-induced CPP using both short and long tests.
Methods
DBA/2J mice were injected with NLX (0 or 10 mg/kg) before three 10- or 60-min choice extinction tests (experiment 1). All mice received a final 60-min test without NLX. Post-test NLX was given in experiment 2. Experiment 3 tested whether NLX would affect a forced extinction procedure. Experiment 4 tested its effect on extinction of cocaine-induced CPP.
Results
Pre-test (but not post-test) injections of NLX-facilitated choice extinction of ethanol CPP at both test durations. Pre-test NLX also facilitated forced extinction. However, pre-test NLX had no effect on choice extinction of cocaine CPP.
Conclusions
Extinction test duration is not critical for engaging the opioid system during ethanol CPP extinction (experiment 1). Moreover, NLX’s effect does not depend on CPP expression during extinction, just exposure to previously conditioned cues (experiment 3). The null effect of post-test NLX eliminates a memory consolidation interpretation (experiment 2) and the failure to alter cocaine CPP extinction argues against alteration of general learning or memory processes (experiment 4). Overall, these data suggest that the endogenous opioid system mediates a conditioned motivational effect that normally maintains alcohol-induced seeking behavior, which may underlie the efficacy of opiate antagonists in the treatment of alcoholism. [-]
Publicado en
Psychopharmacology (2017) 234Proyecto de investigación
R01AA007702Derechos de acceso
(c) Springer-Verlag GmbH Germany 2017
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