The interaction of amino acids with macrocyclic pH probes of pseudopeptidic nature
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Otros documentos de la autoría: Izquierdo Arcusa, María Ángeles; Wadhavane, Prashant Dinkar; Vigara, Laura; Burguete, M. Isabel; Galindo, Francisco; Luis, Santiago V.
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Título
The interaction of amino acids with macrocyclic pH probes of pseudopeptidic natureAutoría
Fecha de publicación
2017Editor
Royal Society of ChemistryISSN
1474-905X; 1474-9092Cita bibliográfica
Photochem. Photobiol. Sci., 2017, 16, 1320Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://pubs.rsc.org/en/content/articlelanding/2017/pp/c7pp00167c#!divAbstractVersión
info:eu-repo/semantics/submittedVersionResumen
The fluorescence quenching, by a series of amino acids, of pseudopeptidic compounds acting as probes for cellular acidity has been investigated. It has been found that amino acids containing electron-rich aromatic ... [+]
The fluorescence quenching, by a series of amino acids, of pseudopeptidic compounds acting as probes for cellular acidity has been investigated. It has been found that amino acids containing electron-rich aromatic side chains like Trp or Tyr, as well as Met quench the emission of the probes mainly via a collisional mechanism, with Stern–Volmer constants in the 7–43 M−1 range, while other amino acids such as His, Val or Phe did not cause deactivation of the fluorescence. Only a minor contribution of a static quenching due to the formation of ground-state complexes has been found for Trp and Tyr, with association constants in the 9–24 M−1 range. For these ground-state complexes, a comparison between the macrocyclic probes and an open chain analogue reveals the existence of a moderate macrocyclic effect due to the preorganization of the probes in the more rigid structure. [-]
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Photochem. Photobiol. Sci., 2017, 16, 1320–1326Proyecto de investigación
CTQ2015-68429-R ; P1·1B-2012-41Derechos de acceso
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