Synthesis of honokiol analogues and evaluation of their modulating action on VEGF protein secretion and telomerase-related gene expressions
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Altres documents de l'autoria: Sanchez Peris, Maria; Murga, Juan; Falomir, Eva; Carda, Miguel; Marco, J. Alberto
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Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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INVESTIGACIONMetadades
Títol
Synthesis of honokiol analogues and evaluation of their modulating action on VEGF protein secretion and telomerase-related gene expressionsData de publicació
2017-04Editor
WileyISSN
1747-0277; 1747-0285Cita bibliogràfica
SÁNCHEZ‐PERIS, María, et al. Synthesis of honokiol analogues and evaluation of their modulating action on VEGF protein secretion and telomerase‐related gene expressions. Chemical biology & drug design, 2017, vol. 89, no 4, p. 577-584.Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://onlinelibrary.wiley.com/doi/10.1111/cbdd.12880/fullVersió
info:eu-repo/semantics/acceptedVersionParaules clau / Matèries
Resum
A group of 36 biphenyl derivatives structurally related to honokiol were synthesized by means of Suzuki coupling reactions. Their cytotoxicities were evaluated and compared to that of honokiol. Some of the compounds ... [+]
A group of 36 biphenyl derivatives structurally related to honokiol were synthesized by means of Suzuki coupling reactions. Their cytotoxicities were evaluated and compared to that of honokiol. Some of the compounds were then evaluated for their ability to downregulate the secretion of the VEGF protein and the expression of the VEGF, hTERT, and c-Myc genes; the two latter involved in the activation of telomerase in tumoral cells. Some of the synthetized derivatives showed promising pharmacological features as they exhibited IC50 values in low micromolar range, good therapeutic margins, and a multiple mode of action on tumor cells based on the inhibition of VEGF and, at the same time, of the expression of genes related to the activation of telomerase. [-]
Publicat a
Chemical biology & drug design, 2017, vol. 89, no 4, p. 577-584Proyecto de investigación
Ministerio de Economia y Competitividad of Spain / CTQ201452949-P; Conselleria d' Empresa, Universitat i Ciencia de la Generalitat Valenciana / PROMETEO/2013/027 and ACOMP/2014/274; University Jaume I / PI-1B2011-37Drets d'accés
Copyright © John Wiley & Sons, Inc.
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info:eu-repo/semantics/openAccess
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info:eu-repo/semantics/openAccess
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