Genetic 3’UTR variation is associated with human pigmentation characteristics and sensitivity to sunlight
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Otros documentos de la autoría: Hernando, Barbara; Peña-Chilet, Maria; Ibarrola-Villava, Maider; Martín González, Manuel; Gómez Fernández, Cristina; Ribas, Gloria; Martinez-Cadenas, Conrado
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Título
Genetic 3’UTR variation is associated with human pigmentation characteristics and sensitivity to sunlightAutoría
Fecha de publicación
2017-10Editor
WileyCita bibliográfica
HERNANDO FUSTER, Bárbara; PEÑA-CHILET, María; IBARROLA-VILLAVA, Maider; MARTÍN GONZÁLEZ, Manuel; GÓMEZ FERNÁNDEZ, Cristina; RIBAS, Gloria; MARTÍNEZ CADENAS, Conrado. Genetic 3’UTR variation is associated with human pigmentation characteristics and sensitivity to sunlight. Experimental Dermatology (2017), v. 26, n. 10, p. 896-903Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://onlinelibrary.wiley.com/doi/10.1111/exd.13333/abstractVersión
info:eu-repo/semantics/sumittedVersionPalabras clave / Materias
Resumen
Sunlight exposure induces signalling pathways leading to the activation of melanin synthesis and tanning response. MicroRNAs (miRNAs) can regulate the expression of genes involved in pigmentation pathways by binding ... [+]
Sunlight exposure induces signalling pathways leading to the activation of melanin synthesis and tanning response. MicroRNAs (miRNAs) can regulate the expression of genes involved in pigmentation pathways by binding to the complementary sequence in their 3′untranslated regions (3′UTRs). Therefore, 3′UTR SNPs are predicted to modify the ability of miRNAs to target genes, resulting in differential gene expression. In this study, we investigated the role in pigmentation and sun-sensitivity traits, as well as in melanoma susceptibility, of 38 different 3′UTR SNPs from 38 pigmentation-related genes. A total of 869 individuals of Spanish origin (526 melanoma cases and 343 controls) were analysed. The association of genotypic data with pigmentation traits was analysed via logistic regression. Web-based tools for predicting the effect of genetic variants in microRNA-binding sites in 3′UTR gene regions were also used. Seven 3′UTR SNPs showed a potential implication in melanoma risk phenotypes. This association is especially noticeable for two of them, rs2325813 in the MLPH gene and rs752107 in the WNT3A gene. These two SNPs were predicted to disrupt a miRNA-binding site and to impact on miRNA-mRNA interaction. To our knowledge, this is the first time that these two 3′UTR SNPs have been associated with sun-sensitivity traits. We state the potential implication of these SNPs in human pigmentation and sensitivity to sunlight, possibly as a result of changes in the level of gene expression through the disruption of putative miRNA-binding sites. [-]
Publicado en
Experimental Dermatology (2017), v. 26, n. 10Proyecto de investigación
1) SCIII-SGEFI/FEDER, Grant/Award Number: PT13/0001; 2) Jaume I University of Castellon under a Predoctoral Research, Grant/Award Number: 15721; 3) Institute Carlos III of the Ministry of Health under a Sara Borrell, Grant/ Award Number: CD15/00153; 4) Institute Carlos III of the Ministry of Health under a Miquel Servet II, Grant/Award Number: CPII14- 00013Derechos de acceso
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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