Effects of lisdexamfetamine and s-citalopram, alone and in combination, on effort-related choice behavior in the rat
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Other documents of the author: Yohn, Samantha E.; López Cruz, Laura; Hutson, Peter H.; Correa, Merce; Salamone, John
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http://dx.doi.org/10.1007/s00213-015-4176-7 |
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Title
Effects of lisdexamfetamine and s-citalopram, alone and in combination, on effort-related choice behavior in the ratDate
2016Publisher
Springer VerlagISSN
0033-3158; 1432-2072Bibliographic citation
Yohn, S.E., Lopez-Cruz, L., Hutson, P.H. et al. Psychopharmacology (2016) 233: 949. doi:10.1007/s00213-015-4176-7Type
info:eu-repo/semantics/articlePublisher version
https://link.springer.com/article/10.1007/s00213-015-4176-7Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Rationale Effort-related motivational symptoms, such as
anergia, psychomotor retardation, and fatigue, are an important
aspect of depression and other disorders. Motivational
symptoms are resistant to some treatments, ... [+]
Rationale Effort-related motivational symptoms, such as
anergia, psychomotor retardation, and fatigue, are an important
aspect of depression and other disorders. Motivational
symptoms are resistant to some treatments, including serotonin
transport (SERT) inhibitors.
Objectives Tests of effort-based choice using operant behavior
tasks (e.g., concurrent lever pressing/ chow feeding tasks)
can be used as animal models of motivational symptoms.
Tests of effort-related choice allow animals to choose between
high-effort actions that lead to more highly valued rewards vs.
low-effort alternatives that lead to less valued rewards (i.e.,
less preferred or lower magnitude). Rats treated with the vesicular
monoamine transport inhibitor tetrabenazine, or the
cytokine interleukin-1β (IL-1β), which are associated with
depressive symptoms in humans, can alter effort-related
choice, reducing selection of the high effort alternative (lever
pressing) while increasing intake of freely available chow.
Methods The present studies focused upon the ability of
lisdexamfetamine (LDX) to increase exertion of effort in rats
responding on effort-based choice tasks under several different
conditions.
Results LDX attenuated the shift from fixed ratio 5 lever
pressing to chow intake induced by tetrabenazine and IL-1β.
In contrast, the SERT inhibitor s-citalopram failed to reverse
the effects of tetrabenazine. When given in combination with
tetrabenazine+s-citalopram, LDX significantly increased lever
pressing output compared to tetrabenaine+citalopram
alone. LDX also increased work output in rats responding
on a progressive ratio/chow feeding choice task.
Conclusions LDX can increase work output in rats
responding on effort-based choice tasks, which may have implications
for understanding the neurochemistry of motivational
symptoms in humans. [-]
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Psychopharmacology (2016) 233:949–960Rights
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