Glutamate and Opioid Antagonists Modulate Dopamine Levels Evoked by Innately Attractive Male Chemosignals in the Nucleus Accumbens of Female Rats
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Otros documentos de la autoría: Sánchez-Catalán, María José; Orrico, Alejandro; Hipólito, Lucía; Zornoza, Teodoro; Polache, Ana; Lanuza, Enrique; Martinez-Garcia, Fernando; Granero, Luis; Agustín-Pavón, Carmen
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Glutamate and Opioid Antagonists Modulate Dopamine Levels Evoked by Innately Attractive Male Chemosignals in the Nucleus Accumbens of Female RatsAutoría
Fecha de publicación
2017-02-23Editor
Frontiers MediaCita bibliográfica
SÁNCHEZ CATALÁN, María José; ORRICO, Alejandro; HIPÓLITO, Lucía; ZORNOZA, Teodoro; POLACHE, Ana; LANUZA, Enrique; MARTÍNEZ GARCÍA, Fernando; GRANERO, Luis; AGUSTÍN-PAVÓN, Carmen. Glutamate and Opioid Antagonists Modulate Dopamine Levels Evoked by Innately Attractive Male Chemosignals in the Nucleus Accumbens of Female Rats. Frontiers in Neuroanatomy (2017), v. 11, pp. 1-15Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://journal.frontiersin.org/article/10.3389/fnana.2017.00008/fullVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Sexual chemosignals detected by vomeronasal and olfactory systems mediate
intersexual attraction in rodents, and act as a natural reinforcer to them. The mesolimbic
pathway processes natural rewards, and the nucleus ... [+]
Sexual chemosignals detected by vomeronasal and olfactory systems mediate
intersexual attraction in rodents, and act as a natural reinforcer to them. The mesolimbic
pathway processes natural rewards, and the nucleus accumbens receives olfactory
information via glutamatergic projections from the amygdala. Thus, the aim of this study
was to investigate the involvement of the mesolimbic pathway in the attraction toward
sexual chemosignals. Our data show that female rats with no previous experience
with males or their chemosignals display an innate preference for male-soiled bedding.
Focal administration of the opioid antagonist b-funaltrexamine into the posterior ventral
tegmental area does not affect preference for male chemosignals. Nevertheless,
exposure to male-soiled bedding elicits an increase in dopamine efflux in the nucleus
accumbens shell and core, measured by microdialysis. Infusion of the opioid antagonist
naltrexone in the accumbens core does not significantly affect dopamine efflux during
exposure to male chemosignals, although it enhances dopamine levels 40 min after
withdrawal of the stimuli. By contrast, infusion of the glutamate antagonist kynurenic
acid in the accumbens shell inhibits the release of dopamine and reduces the time
that females spend investigating male-soiled bedding. These data are in agreement
with previous reports in male rats showing that exposure to opposite-sex odors elicits
dopamine release in the accumbens, and with data in female mice showing that the
behavioral preference for male chemosignals is not affected by opioidergic antagonists.
We hypothesize that glutamatergic projections from the amygdala into the accumbens
might be important to modulate the neurochemical and behavioral responses elicited by
sexual chemosignals in rats. [-]
Publicado en
Frontiers in Neuroanatomy (2017), v. 11Derechos de acceso
info:eu-repo/semantics/openAccess
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