Circulating Betatrophin Levels Are Increased in Anorexia and Decreased in Morbidly Obese Women
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Scholar |
Otros documentos de la autoría: Barja-Fernández, Silvia; Folgueira, Cintia; Seoane, Luisa M.; Casanueva, Felipe F.; Diéguez, Carlos; Castelao, Cecilia; Agüera, Zaida; Baños, Rosa Maria; Botella, Cristina; Torre, Rafael de la; Fernández García, José Carlos; Fernández-Real, José Manuel; Frühbeck, Gema; Gómez Ambrosi, Javier; Jiménez-Murcia, Susana; Tinahones Madueño, Francisco Javier; Estivill, Xavier; Fernández Aranda, Fernando; Nogueiras, Rubén
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Metadatos
Título
Circulating Betatrophin Levels Are Increased in Anorexia and Decreased in Morbidly Obese WomenAutoría
Fecha de publicación
2015-09Editor
Endocrine SocietyCita bibliográfica
BARJA-FERNÁNDEZ, Silvia, et al. Circulating betatrophin levels are increased in anorexia and decreased in morbidly obese women. The Journal of Clinical Endocrinology & Metabolism, 2015, vol. 100, no 9, p. E1188-E1196.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://academic.oup.com/jcem/article-lookup/doi/10.1210/JC.2015-1595Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
betatrophin | body weight | obese women | anorexia nervosa | obesity | body mass index procedure | glucose | morbid | plasma | adipose tissue | insulin | liver
Resumen
Context:
Betatrophin is produced primarily by liver and adipose tissue and has been recently reported as a novel hormone promoting β-cell proliferation and β-cell mass and improving glucose tolerance.
Objective: ... [+]
Context:
Betatrophin is produced primarily by liver and adipose tissue and has been recently reported as a novel hormone promoting β-cell proliferation and β-cell mass and improving glucose tolerance.
Objective:
Because it is markedly regulated by nutritional status, we hypothesized that circulating betatrophin levels might be affected by pathophysiological conditions altering body weight.
Setting and Patients:
We analyzed circulating betatrophin levels in 149 female patients, including 99 with extreme body mass index (30 anorexia nervosa, 24 obese, 45 morbid obese, and 50 healthy eating/weight controls).
Outcome Measurements:
Serum betatrophin levels and its correlations with different anthropometric and biochemical parameters were measured.
Results:
Plasma betatrophin levels were significantly elevated in anorexic patients, whereas its levels were reduced in morbidly obese women when compared with normal-weight women. Plasma betatrophin correlated negatively with weight, body mass index, fat percentage, glucose, insulin, and homeostatic model assessment index and positively correlated with high-density lipoprotein.
Conclusions:
These results suggest that metabolic status is an important regulator of circulating betatrophin levels.
- See more at: http://press.endocrine.org/doi/full/10.1210/JC.2015-1595#sthash.xBpUlVWg.dpuf [-]
Publicado en
The Journal of Clinical Endocrinology & Metabolism, 2015, vol. 100, no 9Derechos de acceso
© 2017 Endocrine Society
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