UHPLC-QTOF MS screening of pharmaceuticals and their metabolitesin treated wastewater samples from Athens
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Other documents of the author: Ibáñez, Maria; Borova, V.; Boix Sales, Clara; Aalizadeh, Reza; Bade, Richard; Thomaidis, Nikolaos; Hernandez, Felix
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comunitat-uji-handle2:10234/33596
comunitat-uji-handle3:10234/33597
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http://dx.doi.org/10.1016/j.jhazmat.2016.03.078 |
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Title
UHPLC-QTOF MS screening of pharmaceuticals and their metabolitesin treated wastewater samples from AthensAuthor (s)
Date
2017-02Publisher
ElsevierBibliographic citation
IBÁÑEZ, M., et al. UHPLC-QTOF MS screening of pharmaceuticals and their metabolites in treated wastewater samples from Athens. Journal of hazardous materials, 2017, vol. 323, p. 26-35.Type
info:eu-repo/semantics/articlePublisher version
http://www.sciencedirect.com/science/article/pii/S0304389416303028Subject
Abstract
After consumption, pharmaceuticals are excreted as parent compounds and/or metabolites in urine and faeces. Some are not completely removed during wastewater treatments, forcing sewage treatment plants (STPs) to apply ... [+]
After consumption, pharmaceuticals are excreted as parent compounds and/or metabolites in urine and faeces. Some are not completely removed during wastewater treatments, forcing sewage treatment plants (STPs) to apply alternative technologies to guarantee quality of treated water. To monitor the removal efficiency of STPs, not only unchanged compounds and metabolites have to be taken into account, but also formation of possible transformation products (TPs). In this work, QTOF MS has been used for screening metabolites/TPs of pharmaceuticals in effluent wastewater from Athens. A customised database was built with the exact masses of metabolites reported in literature for the parent drugs found in an initial screening. Additionally, TPs identified in previous degradation experiments performed at our laboratory were included. Up to 34 metabolites/TPs were detected for omeprazole, venlafaxine, clindamycin, clarithromycin, clopidogrel or dipyrone, among others. Seven corresponded to TPs whose reference standards were available at our lab, seven were TPs previously identified in laboratory degradation experiments, eight were TPs tentatively identified by QTOF MS without reference standards, and twelve TPs were discovered after using the common fragmentation pathway approach. Tentative identification of TPs was supported by prediction of their chromatographic retention time based on the use of advanced chemometric QSRR models. [-]
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Journal of hazardous materials, Volume 323, Part A, February 2017Rights
© 2016 Elsevier B.V. All rights reserved.
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