Synthesis and biological evaluation of simplified pironetin analogues with modifications in the side chain and the lactone ring
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Altres documents de l'autoria: Roldán Gómez, Steven; Cardona, Adrià; Conesa Milián, Laura; Murga, Juan; Falomir, Eva; Carda, Miguel; Marco, J. Alberto
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Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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INVESTIGACIONMetadades
Títol
Synthesis and biological evaluation of simplified pironetin analogues with modifications in the side chain and the lactone ringAutoria
Data de publicació
2017Editor
Royal Society of ChemistryISSN
1477-0520; 1477-0539Cita bibliogràfica
Org. Biomol. Chem., 2017, 15, 220Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://pubs.rsc.org/en/content/articlelanding/2017/ob/c6ob01585a#!divAbstractVersió
info:eu-repo/semantics/acceptedVersionResum
The preparation of several new analogues of the natural dihydropyrone pironetin is described. They differ
from the natural product mainly in the nature of the side chain and the lactone ring. Their cytotoxic
activity ... [+]
The preparation of several new analogues of the natural dihydropyrone pironetin is described. They differ
from the natural product mainly in the nature of the side chain and the lactone ring. Their cytotoxic
activity has been measured. In addition, their interaction with tubulin, their ability to inhibit the secretion
of the vascular endothelial growth factor (VEGF) and the expression of angiogenesis and telomeraserelated
genes have been determined. Unexpectedly, and unlike pironetin, the lactones studied in this
work do not interact with tubulin. Two of the compounds have been found to downregulate the
expression of the hTERT and VEGF genes. Furthermore, one of them causes an appreciably decrease in
the secretion of the VEGF protein. [-]
Publicat a
Org. Biomol. Chem., 2017, 15, 220–232Drets d'accés
This journal is © The Royal Society of Chemistry 2017. Reproduced by permission of The Royal Society of Chemistry
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info:eu-repo/semantics/openAccess
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info:eu-repo/semantics/openAccess
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