Ethanol and Caffeine Effects on Social Interaction and Recognition in Mice: Involvement of Adenosine A(2A) and A(1) Receptors
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Other documents of the author: López Cruz, Laura; San Miguel Segura, Noemí; Bayarri Iturralde, Pilar; Baqi, Younis; Müller, Christa E.; Salomone, John D.; Correa, Merce
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Title
Ethanol and Caffeine Effects on Social Interaction and Recognition in Mice: Involvement of Adenosine A(2A) and A(1) ReceptorsAuthor (s)
Date
2016-11Publisher
Frontiers MediaBibliographic citation
LÓPEZ-CRUZ, Laura, et al. Ethanol and Caffeine effects on social interaction and recognition in mice: Involvement of adenosine A2A and A1 receptors. Frontiers in Behavioral Neuroscience, 2016, vol. 10.Type
info:eu-repo/semantics/articlePublisher version
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090123/Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Ethanol and caffeine are frequently consumed in combination and have opposite
effects on the adenosine system: ethanol metabolism leads to an increase in adenosine
levels, while caffeine is a non-selective adenosine ... [+]
Ethanol and caffeine are frequently consumed in combination and have opposite
effects on the adenosine system: ethanol metabolism leads to an increase in adenosine
levels, while caffeine is a non-selective adenosine A1/A2A receptor antagonist. These
receptors are highly expressed in striatum and olfactory tubercle, brain areas involved
in exploration and social interaction in rodents. Ethanol modulates social interaction
processes, but the role of adenosine in social behavior is still poorly understood.
The present work was undertaken to study the impact of ethanol, caffeine and their
combination on social behavior, and to explore the involvement of A1 and A2A receptors
on those actions. Male CD1 mice were evaluated in a social interaction three-chamber
paradigm, for preference of conspecific vs. object, and also for long-term recognition
memory of familiar vs. novel conspecific. Ethanol showed a biphasic effect, with
low doses (0.25 g/kg) increasing social contact and higher doses (1.0–1.5 g/kg)
reducing social interaction. However, no dose changed social preference; mice
always spent more time sniffing the conspecific than the object, independently of
the ethanol dose. Ethanol, even at doses that did not change social exploration,
produced amnestic effects on social recognition the following day. Caffeine reduced
social contact (15.0–60.0 mg/kg), and even blocked social preference at higher doses
(30.0–60.0 mg/kg). The A1 antagonist Cyclopentyltheophylline (CPT; 3–9 mg/kg) did
not modify social contact or preference on its own, and the A2A antagonist MSX-3
(1.5–6 mg/kg) increased social interaction at all doses. Ethanol at intermediate doses
(0.5–1.0 g/kg) was able to reverse the reduction in social exploration induced by
caffeine (15.0–30.0 mg/kg). Although there was no interaction between ethanol and
CPT or MSX-3 on social exploration in the first day, MSX-3 blocked the amnestic effects
of ethanol observed on the following day. Thus, ethanol impairs the formation of social
memories, and A2A adenosine antagonists can prevent the amnestic effects of ethanol,
so that animals can recognize familiar conspecifics. On the other hand, ethanol can
counteract the social withdrawal induced by caffeine, a non-selective adenosine A1/A2A
receptor antagonist. These results show the complex set of interactions between
ethanol and caffeine, some of which could be the result of the opposing effects they
have in modulating the adenosine system. [-]
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Front Behav Neurosci. 2016; 10: 206.Rights
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