Increased regional gray matter atrophy and enhanced functional connectivy in male multiple sclerosis patients
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Altres documents de l'autoria: Sanchis-Segura, Carla; Cruz Gómez, Álvaro Javier; Belenguer Benavides, Antonio; Fittipaldi Márquez, María Sol; Avila, Cesar; Forn, Cristina
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Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
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comunitat-uji-handle3:10234/8636
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Títol
Increased regional gray matter atrophy and enhanced functional connectivy in male multiple sclerosis patientsAutoria
Data de publicació
2016-09Editor
ElsevierCita bibliogràfica
SANCHIS-SEGURA, C., et al. Increased regional gray matter atrophy and enhanced functional connectivity in male multiple sclerosis patients. Neuroscience Letters, 2016, vol. 630, p. 154-157.Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://www.sciencedirect.com/science/article/pii/S0304394016305225Versió
info:eu-repo/semantics/submittedVersionParaules clau / Matèries
Resum
Evidence suggests that sex/gender is an important factor for understanding multiple sclerosis (MS) and that some of its neuropathological consequences might manifest earlier in males. In the present study, we assessed ... [+]
Evidence suggests that sex/gender is an important factor for understanding multiple sclerosis (MS) and that some of its neuropathological consequences might manifest earlier in males. In the present study, we assessed gray matter (GM) volume and functional connectivity (FC) in a sample of female and male MS patients (MSp) and female and male healthy controls (HCs). As compared to female MSp, male MSp showed decreased GM volume in the bilateral frontal areas and increased FC between different brain regions. Because both sets of changes correlated significantly and no differences in cognitive performance were observed, we suggest that the FC increase observed in male MSp acts as a compensatory mechanism for their more extensive GM loss and that it promotes a functional convergence between male- and female-MSp. [-]
Publicat a
Neuroscience Letters Volume 630, September 2016Drets d'accés
© 2016 Elsevier Ireland Ltd. All rights reserved.
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info:eu-repo/semantics/openAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
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