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Dynamic Peptide Library for the Discovery of Charge Transfer Hydrogels
dc.contributor.author | Berdugo Gumbau, Cristina | |
dc.contributor.author | Nalluri, Siva Krishna Mohan | |
dc.contributor.author | Javid, Nadeem | |
dc.contributor.author | Escuder, Beatriu | |
dc.contributor.author | Miravet, Juan | |
dc.contributor.author | Ulijn, R. V. | |
dc.date.accessioned | 2016-10-21T10:18:08Z | |
dc.date.available | 2016-10-21T10:18:08Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | BERDUGO GUMBAU, Cristina; NALLURI, Siva Krishna Mohan; JAVID, Nadeem; ESCUDER GIL, Beatriu; MIRAVET CELADES, Juan Felipe; ULIJN, R. V. Dynamic Peptide Library for the Discovery of Charge Transfer Hydrogels. ACS Applied Materials & Interfaces (2015), v. 7, n. 46, pp. 25946-25954 | ca_CA |
dc.identifier.uri | http://hdl.handle.net/10234/163763 | |
dc.description.abstract | Coupling of peptide self-assembly to dynamic sequence exchange provides a useful approach for the discovery of self-assembling materials. In here, we demonstrate the discovery and optimization of aqueous, gel-phase nanostructures based on dynamically exchanging peptide sequences that self-select to maximize charge transfer of n-type semiconducting naphthalenediimide (NDI)-dipeptide bioconjugates with various π-electron-rich donors (dialkoxy/hydroxy/amino-naphthalene or pyrene derivatives). These gel-phase peptide libraries are characterized by spectroscopy (UV–vis and fluorescence), microscopy (TEM), HPLC, and oscillatory rheology and it is found that, of the various peptide sequences explored (tyrosine Y-NDI with tyrosine Y, phenylalanine F, leucine L, valine V, alanine A or glycine G-NH2), the optimum sequence is tyrosine-phenylalanine in each case; however, both its absolute and relative yield amplification is dictated by the properties of the donor component, indicating cooperativity of peptide sequence and donor/acceptor pairs in assembly. The methodology provides an in situ discovery tool for nanostructures that enable dynamic interfacing of supramolecular electronics with aqueous (biological) systems. | ca_CA |
dc.description.sponsorShip | This work was funded by the US Air Force (AFOSR, grant 12448RK7359A), the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no. 258775 and the Ministry of Science and Innovation of Spain (CTQ2009-13961 grant). | ca_CA |
dc.format.extent | 9 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | ACS Publications | ca_CA |
dc.relation.isPartOf | ACS Applied Materials & Interfaces (2015), v. 7, n. 46 | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/CNE/1.0/ | * |
dc.subject | Charge transfer interactions | ca_CA |
dc.subject | Dynamic combinatorial libraries | ca_CA |
dc.subject | Hydrogels | ca_CA |
dc.subject | Peptide derivatives | ca_CA |
dc.subject | Self-assembly | ca_CA |
dc.subject | Supramolecular electronics | ca_CA |
dc.subject | Thermolysin | ca_CA |
dc.title | Dynamic Peptide Library for the Discovery of Charge Transfer Hydrogels | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1021/acsami.5b08968 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | http://pubs.acs.org/doi/abs/10.1021/acsami.5b08968 | ca_CA |
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