Serum Malondialdehyde Concentration and Glutathione Peroxidase Activity in a Longitudinal Study of Gestational Diabetes
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Other documents of the author: Arribas, Luis; Almansa, Inmaculada; Miranda, M.; Muriach Saurí, María; Romero, Francisco J.; Villar, Vincent M.
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comunitat-uji-handle3:10234/36082
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INVESTIGACIONMetadata
Title
Serum Malondialdehyde Concentration and Glutathione Peroxidase Activity in a Longitudinal Study of Gestational DiabetesAuthor (s)
Date
2016Publisher
Public Library of ScienceISSN
1932-6203Bibliographic citation
ARRIBAS, Luis, et al. Serum Malondialdehyde Concentration and Glutathione Peroxidase Activity in a Longitudinal Study of Gestational Diabetes. PloS one, 2016, vol. 11, no 5, p. e0155353.Type
info:eu-repo/semantics/articleSubject
Abstract
Aims
The main goal of this study was to evaluate the presence of oxidative damage and to quantify its level in gestational diabetes.
Methods
Thirty-six healthy women and thirty-six women with gestational ... [+]
Aims
The main goal of this study was to evaluate the presence of oxidative damage and to quantify its level in gestational diabetes.
Methods
Thirty-six healthy women and thirty-six women with gestational diabetes were studied in the three trimesters of pregnancy regarding their levels of oxidative stress markers. These women were diagnosed with diabetes in the second trimester of pregnancy. Blood glucose levels after 100g glucose tolerance test were higher than 190, 165 or 145 mg/dl, 1, 2 or 3 hours after glucose intake.
Results
The group of women with gestational diabetes had higher serum malondialdehyde levels, with significant differences between groups in the first and second trimester. The mean values of serum glutathione peroxidase activity in the diabetic women were significantly lower in the first trimester. In the group of women with gestational diabetes there was a negative linear correlation between serum malondialdehyde concentration and glutathione peroxidase activity in the second and third trimester.
Conclusions
In this observational and longitudinal study in pregnant women, the alterations attributable to oxidative stress were present before the biochemical detection of the HbA1c increase. Usual recommendations once GD is detected (adequate metabolic control, as well as any other normally proposed to these patients) lowered the concentration of malondialdehyde at the end of pregnancy to the same levels of the healthy controls. Serum glutathione peroxidase activity in women with gestational diabetes increased during the gestational period. [-]
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PloS one, 2016, vol. 11, no 5Rights
info:eu-repo/semantics/openAccess
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