Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions
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Other documents of the author: Sanchez Peris, Maria; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto
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comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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INVESTIGACIONMetadata
Title
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressionsDate
2016Publisher
ElsevierISSN
0968-0896; 1464-3391Type
info:eu-repo/semantics/articlePublisher version
http://www.sciencedirect.com/science/article/pii/S0968089616303546Subject
Abstract
A group of 47 biphenyl functionalized compounds, prepared by means of Suzuki couplings, has been
investigated for their cytotoxicity on two tumoral cell lines (HT-29 and MCF-7) and one non tumoral cell
line (HEK-293). ... [+]
A group of 47 biphenyl functionalized compounds, prepared by means of Suzuki couplings, has been
investigated for their cytotoxicity on two tumoral cell lines (HT-29 and MCF-7) and one non tumoral cell
line (HEK-293). 29 selected compounds have been investigated for their ability to inhibit the production
of the vascular endothelial growth factor (VEGF). Subsequently, the capacity of the compounds to downregulate
the expression of the VEGF, h-TERT and c-Myc genes, the two latter involved in the control of the
activation of telomerase, has also been determined. [-]
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Bioorganic & Medicinal Chemistry 24 (2016) 3108–3115Rights
2016 Elsevier Ltd. All rights reserved.
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info:eu-repo/semantics/openAccess
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info:eu-repo/semantics/openAccess
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