Research of antitumoral compounds
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Title
Research of antitumoral compoundsAuthor (s)
Tutor/Supervisor
Falomir Ventura, EvaTutor/Supervisor; University.Department
Universitat Jaume I. Departament de Química Inorgànica i OrgànicaDate
2014Publisher
Universitat Jaume IAbstract
The main idea is to explore colchicine derivatives as potential inhibitors of cellular
division. It has been explained that colchicine is an antimitotic compound which stops
or inhibits the cellular division. The ... [+]
The main idea is to explore colchicine derivatives as potential inhibitors of cellular
division. It has been explained that colchicine is an antimitotic compound which stops
or inhibits the cellular division. The main problem is that colchicine has a narrow
therapeutic margin, which means that efficient and toxic doses are very similar.
This research line is focused in the developing derivatives of colchicine with
better therapeutic margin and improved antitumor activity. In addition, more tests
are going to be carried out in order to determine if these new compounds have
inhibition abilities over certain genes related to cancer activities. In this case,
modifications over the acetamide group of the colchicine are going to be carried and
it is going to be substituted with different regioisomers of chlorobenzoic acid. Hence,
the objectives are: Synthesis of colchicine derivatives from 2-, 3-, and 4-chlorobenzoic acid. Evaluation of the biological activity of synthesized compounds. [-]
Subject
Description
Treball Final de Grau en Química. Codi: QU0943. Curs: 2014/2015
Type
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